Extent of primary DNA damage measured by the comet assay in health professionals exposed to antineoplastic drugs: A systematic review and meta-analysis

Vincenza Gianfredi, Daniele Nucci, Cristina Fatigoni, Tania Salvatori, Milena Villarini, Massimo Moretti

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Antineoplastic drugs (ANDs) are a broad group of chemicals showing, at the same time, carcinogenic effects. The potential, albeit true, risk of side effects cannot be accepted, especially if resulting from occupational exposure. The aim of this study was to evaluate the association between occupational exposure to ANDs and the extent of primary DNA damage in health professionals. Methods: A systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed/Medline, Web of Science, and Scopus were used to perform the literature search. The databases were examined in July 2019. Sub-group, moderator, and cumulative analyses were conducted. The trim and fill method was used in the case of potential publication bias. Results: Twenty studies were included in the qualitative analysis, and 19 in quantitative evaluation. The pooled effect size was 1.27 [(95% confidence interval (CI) = 0.66–1.88), p = 0.000] based on 1569 subjects. The moderator analysis by duration of exposure showed a positive association between duration of exposure and primary DNA damage. Conclusions: This systematic review clearly shows a significant association between occupational exposure to ANDs and the extent of primary DNA damage in health professionals. Considering these results, health professionals should be warned against this potential occupational risk.

Original languageEnglish
Article number523
Pages (from-to)1-21
Number of pages21
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number2
DOIs
Publication statusPublished - Jan 14 2020

Keywords

  • Antineoplastic drugs
  • Comet assay
  • Health personnel
  • Occupational exposure
  • Single-cell gel-electrophoresis

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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