External beam radiotherapy in elderly patients with clinically localized prostate adenocarcinoma: Age is not a problem

Sergio Villa, Nice Bedini, Carlo Fallai, Patrizia Olmi

Research output: Contribution to journalArticlepeer-review

Abstract

The files of 183 elderly patients aged >70 years, with localized prostate cancer (T1-3, N0-X, M0), treated with radical external radiation therapy (ERT) from January 1992 to December 2001 at the Radiotherapy Department of the Istituto Nazionale Tumori of Milan, were reviewed. Median age was 75 years. ERT represented the sole treatment for 73 patients (39.9%); in 110 cases (60.1%) hormonal therapy (HT) was associated with neoadjuvant intent. Five-year overall, disease-specific and biochemical NED (bNED) survival rates were 90.2, 93.7 and 63.2%, respectively. A subset of 23 patients aged 80 years and over were analyzed and compared to 160 men aged 70-79 years. Acute toxicity and late complications were analyzed in the two groups of patients according to the RTOG scoring system. Only 10 patients (5.4%) showed grades 2-3 (G2-3) late sequelae. The results obtained in this single-institute series highlight the pivotal role of ERT in the management of clinically localized prostate cancer in the elderly.

Original languageEnglish
Pages (from-to)215-225
Number of pages11
JournalCritical Reviews in Oncology/Hematology
Volume48
Issue number2
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Elderly
  • Prostate cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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