External quality control of Mycobacterium tuberculosis drug susceptibility testing: Results of two rounds in endemic countries

Lanfranco Fattorini, E. Iona, D. Cirillo, G. B. Migliori, G. Orefici, M. Aziz, A. Wright, S. Tafaj, B. Baig, G. Mulliqi, S. Maungate, Z. Cuna, S. Al-Busaidy, Z. Al-Suwaidi, I. Ceyhan

Research output: Contribution to journalArticlepeer-review

Abstract

SETTING: Quality assurance for the World Health Organization (WHO)/International Union Against Tuberculosis and Lung Disease (The Union) global tuberculosis (TB) drug resistance surveillance programme. OBJECTIVE: To monitor the quality of drug susceptibility testing (DST) in different countries. METHODS: In 2002-2003 and 2005-2006, 20 Mycobacterium tuberculosis strains were sent by the WHO/Union Supranational Reference Laboratory of Rome to TB reference laboratories in Albania, Bahrain, Kosovo, Mozambique, Oman, Qatar and Turkey for external quality control (EQC). RESULTS: In 2002-2003, the specificity, sensitivity, efficiency, reproducibility and predictive values for resistance/susceptibility were ≥90% for streptomycin (SM), isoniazid (INH) and ethambutol (EMB). In 2005-2006, all statistical values were ≥96% for SM, INH, rifampicin and EMB. CONCLUSION: EQC improved the quality of M. tuberculosis DST in the participating countries.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume12
Issue number2
Publication statusPublished - Feb 2008

Keywords

  • Drug susceptibility testing
  • External quality control
  • Mycobacterium tuberculosis
  • WHO/Union Supranational Reference Laboratories

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'External quality control of Mycobacterium tuberculosis drug susceptibility testing: Results of two rounds in endemic countries'. Together they form a unique fingerprint.

Cite this