External Validation Confirms Validity of a Simple Model to Predict Bowel Outcome After Traumatic Spinal Cord Injury

Chiara Pavese, Giorgio Scivoletto, Mariangela V. Puci, Martin Schubert, Armin Curt, Enrico Finazzi Agrò, Cristina Montomoli, Thomas M. Kessler

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The prediction of functional outcomes after spinal cord injury (SCI) is essential to plan the rehabilitation phase and the social reintegration. Recently, 2 models to predict independent and reliable bowel management 1 year after traumatic SCI have been derived and validated in 2 cohorts of patients included in the European Multicenter Study about Spinal Cord Injury (EMSCI). Objective. We aimed to validate 2 prediction models for bowel outcome after traumatic SCI in a patient sample external to EMSCI. Methods. The simplified model (based on a single predictor, the International Standards for Neurological Classification of Spinal Cord Injury [ISNCSCI] total motor score) and the full model (based on 2 predictors, the ISNCSCI total motor score and item 3a of the Spinal Cord Independence Measure) were applied to the retrospectively collected data of 111 patients with traumatic SCI. Results. The simplified and the full models showed excellent discrimination with an area under the receiver operating characteristic curve of.939 (95% confidence interval (CI).87-1.00) and.922 (95% CI 0.85-.99), respectively. Both models displayed similar results for sensitivity and negative predictive values; however, the simplified model showed higher values for specificity, positive predictive values, and accuracy. The calibration analysis showed a partial overlap between predicted probabilities and observed proportion, with better and acceptable calibration for the simplified model. Conclusions. Using an independent sample, our study demonstrates the validity of a simple model to predict independent and reliable bowel management 1 year after traumatic SCI.

Original languageEnglish
JournalNeurorehabilitation and Neural Repair
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • bowel function
  • cohort study
  • prediction
  • rehabilitation
  • spinal cord injury
  • validation

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

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