Extinction partially reverts structural changes associated with remote fear memory

Gisella Vetere, Leonardo Restivo, Giovanni Novembre, Massimiliano Aceti, Massimo Lumaca, Martine Ammassari-Teule

Research output: Contribution to journalArticle

Abstract

Structural synaptic changes occur in medial prefrontal cortex circuits during remote memory formation. Whether extinction reverts or further reshapes these circuits is, however, unknown. Here we show that the number and the size of spines were enhanced in anterior cingulate (aCC) and infralimbic (ILC) cortices 36 d following contextual fear conditioning. Upon extinction, aCC spine density returned to baseline, but the enhanced proportion of large spines did not. Differently, ILC spine density remained elevated, but the size of spines decreased dramatically. Thus, extinction partially erases the remote memory network, suggesting that the preserved network properties might sustain reactivation of extinguished conditioned fear.

Original languageEnglish
Pages (from-to)554-557
Number of pages4
JournalLearning and Memory
Volume18
Issue number9
DOIs
Publication statusPublished - Sep 2011

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

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    Vetere, G., Restivo, L., Novembre, G., Aceti, M., Lumaca, M., & Ammassari-Teule, M. (2011). Extinction partially reverts structural changes associated with remote fear memory. Learning and Memory, 18(9), 554-557. https://doi.org/10.1101/lm.2246711