Complicanze infettive gravi extra-cerebrali in pazienti affetti da teleangectasia emorragica ereditaria (Malattia di Rendu-Osler-Weber). Cinque casi clinici e revisione della letteratura

Translated title of the contribution: Extra-cerebral severe infections associated with haemorrhagic hereditary telangiectasia (Rendu-Osler- Weber Disease): Five cases and a review of the literature

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hereditary haemorrhagic telangiectasia (HHT) is one of the most common autosomal dominant disorders and is characterized by genetically determined abnormalities of vascular structure. People affected by HHT are predisposed to severe infections such as cerebral abscesses, typical of patients with pulmonary arteriovenous malformations, and extra-cerebral infections such as bacteraemia, septic arthritis, osteomyelitis, hepatic abscesses, skin infections and infective endocarditis. We present a retrospective series of severe bacterial extra-cerebral infections in five patients affected by HHT, admitted to our Institute from January 2007 to June 2013. We also reviewed the literature of the last five years concerning infectious complications in people affected by HHT. Our study shows that HHT patients with infectious complications exclusively localized in extra-cerebral sites are usually fragile, old and affected by comorbidities. Moreover, we recognized a trend of Staphylococcus aureus (SA) severe infection recurrence in such patients, both in our series and in the literature. In our opinion these results suggest the need to evaluate the possible benefits of SA nasal colonization screening and decolonization in such patients.

Original languageItalian
Pages (from-to)50-56
Number of pages7
JournalInfezioni in Medicina
Volume22
Issue number1
Publication statusPublished - 2014

Fingerprint

Hereditary Hemorrhagic Telangiectasia
Infection
Staphylococcus aureus
Intracranial Arteriovenous Malformations
Liver Abscess
Infectious Arthritis
Brain Abscess
Osteomyelitis
Bacteremia
Endocarditis
Nose
Blood Vessels
Comorbidity
Recurrence
Lung
Skin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

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title = "Complicanze infettive gravi extra-cerebrali in pazienti affetti da teleangectasia emorragica ereditaria (Malattia di Rendu-Osler-Weber). Cinque casi clinici e revisione della letteratura",
abstract = "Hereditary haemorrhagic telangiectasia (HHT) is one of the most common autosomal dominant disorders and is characterized by genetically determined abnormalities of vascular structure. People affected by HHT are predisposed to severe infections such as cerebral abscesses, typical of patients with pulmonary arteriovenous malformations, and extra-cerebral infections such as bacteraemia, septic arthritis, osteomyelitis, hepatic abscesses, skin infections and infective endocarditis. We present a retrospective series of severe bacterial extra-cerebral infections in five patients affected by HHT, admitted to our Institute from January 2007 to June 2013. We also reviewed the literature of the last five years concerning infectious complications in people affected by HHT. Our study shows that HHT patients with infectious complications exclusively localized in extra-cerebral sites are usually fragile, old and affected by comorbidities. Moreover, we recognized a trend of Staphylococcus aureus (SA) severe infection recurrence in such patients, both in our series and in the literature. In our opinion these results suggest the need to evaluate the possible benefits of SA nasal colonization screening and decolonization in such patients.",
author = "Maria Musso and Alessandro Capone and Pierangelo Chinello and Bella, {Stefano Di} and Vincenzo Galati and Pasquale Noto and Fabrizio Taglietti and Simone Topino and Nicola Petrosillo",
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AU - Capone, Alessandro

AU - Chinello, Pierangelo

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AU - Noto, Pasquale

AU - Taglietti, Fabrizio

AU - Topino, Simone

AU - Petrosillo, Nicola

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