Extra-gastrointestinal stromal tumor of the pancreas: Case report and review of the literature

Valentina Beltrame, Mario Gruppo, Davide Pastorelli, Sara Pizzi, Stefano Merigliano, Cosimo Sperti

Research output: Contribution to journalArticlepeer-review


Primary extra-gastrointestinal stromal tumor (EGISTs) arising in the pancreas is extremely rare: only 20 cases have previously been reported in the English literature from 2000 to 2013. We reported a case of EGIST of the pancreas in a 69-year-old woman who presented with abdominal pain and with a solid, heterogeneously enhancing neoplasm in the uncinate process of the pancreas, revealed preoperatively by an abdominal computed tomography scan. A diagnosis of neuroendocrine tumor was suggested. Positron emission tomography with 68Ga-DOTATOC did not show pathological accumulation of the tracer in the pancreas. The patient underwent enucleation, under ultrasonic guidance, of the pancreatic tumor that emerged to the surface of the pancreas. Histopathology and immunohistochemical examination confirmed the final diagnosis of EGIST of the pancreas (CD117+), with one mitosis per 50 high-power fields. Although rarely, GIST can involve the pancreas as a primary site, and this tumor should be considered in the differential diagnosis of pancreatic neoplasms.

Original languageEnglish
Article number105
JournalWorld Journal of Surgical Oncology
Issue number1
Publication statusPublished - Apr 23 2014


  • Differential diagnosis
  • Gastrointestinal stromal tumor
  • Pancreas
  • Pancreatectomy
  • Pancreatic neoplasms

ASJC Scopus subject areas

  • Oncology
  • Surgery


Dive into the research topics of 'Extra-gastrointestinal stromal tumor of the pancreas: Case report and review of the literature'. Together they form a unique fingerprint.

Cite this