Extra-natriuretic effects of atrial peptide in humans

Luca De Nicola, Giulio Romano, Bruno Memoli, Bruno Cianciaruso, Massimo Sabbatini, Domenico Russo, Alfredo Caglioti, Giorgio Fuiano, Antonio Dal Canton, Giuseppe Conte

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To evaluate extra-natriuretic effects of atrial natriuretic peptide (ANP), plasma ANP (pANP) levels were assessed in seven healthy men on low-sodium diet (80 mEq NaCl/day), in basal conditions and during stepwise infusion of human ANP (2, 4, 8 and 16 ng/min/kg). To determine the individual physiological (PHY) pANP level, we measured pANP in the same subjects after a high-salt diet (400 mEq NaCl/day), that is, in a physiological stimulation of ANP. We then compared the effects of the PHY levels of ANP to the effects of pharmacological (PHA) pANP levels. Neither PHY nor PHA pANP levels modified creatinine clearante or blood pressure. The progressive rise in pANP levels was associated with increases in urinary excretion of Na+, K+ and area. ANP alone respectively accounted for 41%, 30% and 92% of the increase in natriuresis, kaliuresis and urea excretion that occurred after changing salt intake fronl 80 to 400 mEq/day. Pharmacological ANP levels raised CH2O and reduced UOsm. Interestingly, PHA levels were associated with significant decrease in serum K+ (from 4.5 ± .1 to 4.0 ± .1 mEq/liter) and plasma urea (from 31.9 ± 5 to 24.2 ± 4 mg/dl). The mean cumulative urinary potassium and urea losses corresponded to the theoretical body losses of potassium and urea; moreover, the individual cumulative urinary losses of potassium and urea signiticantly correlated with the corresponding decrement in their plasma levels. In conclusion, ANP has both physiological and pharmacological significance in the control of potassium and urea metabolism by decreasing plasma levels of K+ and urea through effects on the renal excretory function.

Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalKidney International
Volume43
Issue number2
Publication statusPublished - Feb 1993

Fingerprint

Natriuretic Agents
Atrial Natriuretic Factor
Urea
Pharmacology
Potassium
antiarrhythmic peptide
Salts
Sodium-Restricted Diet
Natriuresis

ASJC Scopus subject areas

  • Nephrology

Cite this

De Nicola, L., Romano, G., Memoli, B., Cianciaruso, B., Sabbatini, M., Russo, D., ... Conte, G. (1993). Extra-natriuretic effects of atrial peptide in humans. Kidney International, 43(2), 307-313.

Extra-natriuretic effects of atrial peptide in humans. / De Nicola, Luca; Romano, Giulio; Memoli, Bruno; Cianciaruso, Bruno; Sabbatini, Massimo; Russo, Domenico; Caglioti, Alfredo; Fuiano, Giorgio; Dal Canton, Antonio; Conte, Giuseppe.

In: Kidney International, Vol. 43, No. 2, 02.1993, p. 307-313.

Research output: Contribution to journalArticle

De Nicola, L, Romano, G, Memoli, B, Cianciaruso, B, Sabbatini, M, Russo, D, Caglioti, A, Fuiano, G, Dal Canton, A & Conte, G 1993, 'Extra-natriuretic effects of atrial peptide in humans', Kidney International, vol. 43, no. 2, pp. 307-313.
De Nicola L, Romano G, Memoli B, Cianciaruso B, Sabbatini M, Russo D et al. Extra-natriuretic effects of atrial peptide in humans. Kidney International. 1993 Feb;43(2):307-313.
De Nicola, Luca ; Romano, Giulio ; Memoli, Bruno ; Cianciaruso, Bruno ; Sabbatini, Massimo ; Russo, Domenico ; Caglioti, Alfredo ; Fuiano, Giorgio ; Dal Canton, Antonio ; Conte, Giuseppe. / Extra-natriuretic effects of atrial peptide in humans. In: Kidney International. 1993 ; Vol. 43, No. 2. pp. 307-313.
@article{d87866017a7c4785ba30fe3b47a36843,
title = "Extra-natriuretic effects of atrial peptide in humans",
abstract = "To evaluate extra-natriuretic effects of atrial natriuretic peptide (ANP), plasma ANP (pANP) levels were assessed in seven healthy men on low-sodium diet (80 mEq NaCl/day), in basal conditions and during stepwise infusion of human ANP (2, 4, 8 and 16 ng/min/kg). To determine the individual physiological (PHY) pANP level, we measured pANP in the same subjects after a high-salt diet (400 mEq NaCl/day), that is, in a physiological stimulation of ANP. We then compared the effects of the PHY levels of ANP to the effects of pharmacological (PHA) pANP levels. Neither PHY nor PHA pANP levels modified creatinine clearante or blood pressure. The progressive rise in pANP levels was associated with increases in urinary excretion of Na+, K+ and area. ANP alone respectively accounted for 41{\%}, 30{\%} and 92{\%} of the increase in natriuresis, kaliuresis and urea excretion that occurred after changing salt intake fronl 80 to 400 mEq/day. Pharmacological ANP levels raised CH2O and reduced UOsm. Interestingly, PHA levels were associated with significant decrease in serum K+ (from 4.5 ± .1 to 4.0 ± .1 mEq/liter) and plasma urea (from 31.9 ± 5 to 24.2 ± 4 mg/dl). The mean cumulative urinary potassium and urea losses corresponded to the theoretical body losses of potassium and urea; moreover, the individual cumulative urinary losses of potassium and urea signiticantly correlated with the corresponding decrement in their plasma levels. In conclusion, ANP has both physiological and pharmacological significance in the control of potassium and urea metabolism by decreasing plasma levels of K+ and urea through effects on the renal excretory function.",
author = "{De Nicola}, Luca and Giulio Romano and Bruno Memoli and Bruno Cianciaruso and Massimo Sabbatini and Domenico Russo and Alfredo Caglioti and Giorgio Fuiano and {Dal Canton}, Antonio and Giuseppe Conte",
year = "1993",
month = "2",
language = "English",
volume = "43",
pages = "307--313",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Extra-natriuretic effects of atrial peptide in humans

AU - De Nicola, Luca

AU - Romano, Giulio

AU - Memoli, Bruno

AU - Cianciaruso, Bruno

AU - Sabbatini, Massimo

AU - Russo, Domenico

AU - Caglioti, Alfredo

AU - Fuiano, Giorgio

AU - Dal Canton, Antonio

AU - Conte, Giuseppe

PY - 1993/2

Y1 - 1993/2

N2 - To evaluate extra-natriuretic effects of atrial natriuretic peptide (ANP), plasma ANP (pANP) levels were assessed in seven healthy men on low-sodium diet (80 mEq NaCl/day), in basal conditions and during stepwise infusion of human ANP (2, 4, 8 and 16 ng/min/kg). To determine the individual physiological (PHY) pANP level, we measured pANP in the same subjects after a high-salt diet (400 mEq NaCl/day), that is, in a physiological stimulation of ANP. We then compared the effects of the PHY levels of ANP to the effects of pharmacological (PHA) pANP levels. Neither PHY nor PHA pANP levels modified creatinine clearante or blood pressure. The progressive rise in pANP levels was associated with increases in urinary excretion of Na+, K+ and area. ANP alone respectively accounted for 41%, 30% and 92% of the increase in natriuresis, kaliuresis and urea excretion that occurred after changing salt intake fronl 80 to 400 mEq/day. Pharmacological ANP levels raised CH2O and reduced UOsm. Interestingly, PHA levels were associated with significant decrease in serum K+ (from 4.5 ± .1 to 4.0 ± .1 mEq/liter) and plasma urea (from 31.9 ± 5 to 24.2 ± 4 mg/dl). The mean cumulative urinary potassium and urea losses corresponded to the theoretical body losses of potassium and urea; moreover, the individual cumulative urinary losses of potassium and urea signiticantly correlated with the corresponding decrement in their plasma levels. In conclusion, ANP has both physiological and pharmacological significance in the control of potassium and urea metabolism by decreasing plasma levels of K+ and urea through effects on the renal excretory function.

AB - To evaluate extra-natriuretic effects of atrial natriuretic peptide (ANP), plasma ANP (pANP) levels were assessed in seven healthy men on low-sodium diet (80 mEq NaCl/day), in basal conditions and during stepwise infusion of human ANP (2, 4, 8 and 16 ng/min/kg). To determine the individual physiological (PHY) pANP level, we measured pANP in the same subjects after a high-salt diet (400 mEq NaCl/day), that is, in a physiological stimulation of ANP. We then compared the effects of the PHY levels of ANP to the effects of pharmacological (PHA) pANP levels. Neither PHY nor PHA pANP levels modified creatinine clearante or blood pressure. The progressive rise in pANP levels was associated with increases in urinary excretion of Na+, K+ and area. ANP alone respectively accounted for 41%, 30% and 92% of the increase in natriuresis, kaliuresis and urea excretion that occurred after changing salt intake fronl 80 to 400 mEq/day. Pharmacological ANP levels raised CH2O and reduced UOsm. Interestingly, PHA levels were associated with significant decrease in serum K+ (from 4.5 ± .1 to 4.0 ± .1 mEq/liter) and plasma urea (from 31.9 ± 5 to 24.2 ± 4 mg/dl). The mean cumulative urinary potassium and urea losses corresponded to the theoretical body losses of potassium and urea; moreover, the individual cumulative urinary losses of potassium and urea signiticantly correlated with the corresponding decrement in their plasma levels. In conclusion, ANP has both physiological and pharmacological significance in the control of potassium and urea metabolism by decreasing plasma levels of K+ and urea through effects on the renal excretory function.

UR - http://www.scopus.com/inward/record.url?scp=0027198838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027198838&partnerID=8YFLogxK

M3 - Article

C2 - 8441227

AN - SCOPUS:0027198838

VL - 43

SP - 307

EP - 313

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 2

ER -