Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis

G. Banfi, E. Imbasciati, L. Guerra, M. J. Mihatsch, C. Ponticelli

Research output: Contribution to journalArticle

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Abstract

Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunofluorescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid 'pulse', antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is suggested.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalNephron
Volume33
Issue number1
Publication statusPublished - 1983

Fingerprint

Penicillamine
Glomerulonephritis
Vasculitis
Rheumatoid Arthritis
Kidney
Anuria
Platelet Aggregation Inhibitors
Recovery of Function
Immunoglobulin A
Fluorescent Antibody Technique
Pulse
Heparin
Microscopy
Steroids
Light

ASJC Scopus subject areas

  • Nephrology

Cite this

Banfi, G., Imbasciati, E., Guerra, L., Mihatsch, M. J., & Ponticelli, C. (1983). Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis. Nephron, 33(1), 56-60.

Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis. / Banfi, G.; Imbasciati, E.; Guerra, L.; Mihatsch, M. J.; Ponticelli, C.

In: Nephron, Vol. 33, No. 1, 1983, p. 56-60.

Research output: Contribution to journalArticle

Banfi, G, Imbasciati, E, Guerra, L, Mihatsch, MJ & Ponticelli, C 1983, 'Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis', Nephron, vol. 33, no. 1, pp. 56-60.
Banfi G, Imbasciati E, Guerra L, Mihatsch MJ, Ponticelli C. Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis. Nephron. 1983;33(1):56-60.
Banfi, G. ; Imbasciati, E. ; Guerra, L. ; Mihatsch, M. J. ; Ponticelli, C. / Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis. In: Nephron. 1983 ; Vol. 33, No. 1. pp. 56-60.
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