Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis

G. Banfi; E. Imbasciati; L. Guerra; M. J. Mihatsch; C. Ponticelli

Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis

G. Banfi, E. Imbasciati, L. Guerra, M. J. Mihatsch, C. Ponticelli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunofluorescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid 'pulse', antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is suggested.

Original language	English
Pages (from-to)	56-60
Number of pages	5
Journal	Nephron
Volume	33
Issue number	1
Publication status	Published - 1983

ASJC Scopus subject areas

Nephrology

Fingerprint Dive into the research topics of 'Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this

@article{91956f8636ee4b66a933ecf1da69e21f,

title = "Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis",

abstract = "Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunofluorescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid 'pulse', antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is suggested.",

author = "G. Banfi and E. Imbasciati and L. Guerra and Mihatsch, {M. J.} and C. Ponticelli",

year = "1983",

language = "English",

volume = "33",

pages = "56--60",

journal = "Experimental Nephrology",

issn = "0028-2766",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Extracapillary glomerulonephritis with necrotizing vasculitis in D-penicillamine-treated rheumatoid arthritis

AU - Banfi, G.

AU - Imbasciati, E.

AU - Guerra, L.

AU - Mihatsch, M. J.

AU - Ponticelli, C.

PY - 1983

Y1 - 1983

N2 - Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunofluorescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid 'pulse', antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is suggested.

AB - Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunofluorescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid 'pulse', antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is suggested.

UR - http://www.scopus.com/inward/record.url?scp=0020684466&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020684466&partnerID=8YFLogxK

M3 - Article

C2 - 6339966

AN - SCOPUS:0020684466

VL - 33

SP - 56

EP - 60

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 1

ER -