Abstract
Cyclic ADP-ribose (cADPR) is a universal second messenger that regulates many calcium-related cellular events by releasing calcium from intracellular stores. Since these events include enhanced cell proliferation and since the bone marrow harbors both ectoenzymes that generate cADPR from NAD+ (CD38 and BST-1), we investigated the effects of extracellular cADPR on human hemopoietic progenitors (HP). Exposure of HP to 100 μM cADPR for 24 h induced a significant increase in colony output (P
Original language | English |
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Pages (from-to) | 680-690 |
Number of pages | 11 |
Journal | FASEB Journal |
Volume | 14 |
Issue number | 5 |
Publication status | Published - 2000 |
Keywords
- Bone marrow cells
- Cytokine-like activity of cyclic ADP-ribose
- Expansion of hemopoietic progenitors
- Intracellular calcium homeostasis
ASJC Scopus subject areas
- Agricultural and Biological Sciences (miscellaneous)
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology