Extracelluar cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors

Marina Podestà, Elena Zocchi, Anna Pitto, Cesare Usai, Luisa Franco, Santina Bruzzone, Lucrezia Guida, Andrea Bacigalupo, David T. Scadden, Timothy F. Walseth, Antonio De Flora, Antonio Daga

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclic ADP-ribose (cADPR) is a universal second messenger that regulates many calcium-related cellular events by releasing calcium from intracellular stores. Since these events include enhanced cell proliferation and since the bone marrow harbors both ectoenzymes that generate cADPR from NAD+ (CD38 and BST-1), we investigated the effects of extracellular cADPR on human hemopoietic progenitors (HP). Exposure of HP to 100 μM cADPR for 24 h induced a significant increase in colony output (P

Original languageEnglish
Pages (from-to)680-690
Number of pages11
JournalFASEB Journal
Volume14
Issue number5
Publication statusPublished - 2000

Keywords

  • Bone marrow cells
  • Cytokine-like activity of cyclic ADP-ribose
  • Expansion of hemopoietic progenitors
  • Intracellular calcium homeostasis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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