Extracelluar cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors

Marina Podestà; Elena Zocchi; Anna Pitto; Cesare Usai; Luisa Franco; Santina Bruzzone; Lucrezia Guida; Andrea Bacigalupo; David T. Scadden; Timothy F. Walseth; Antonio De Flora; Antonio Daga

Extracelluar cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors

Marina Podestà, Elena Zocchi, Anna Pitto, Cesare Usai, Luisa Franco, Santina Bruzzone, Lucrezia Guida, Andrea Bacigalupo, David T. Scadden, Timothy F. Walseth, Antonio De Flora, Antonio Daga

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclic ADP-ribose (cADPR) is a universal second messenger that regulates many calcium-related cellular events by releasing calcium from intracellular stores. Since these events include enhanced cell proliferation and since the bone marrow harbors both ectoenzymes that generate cADPR from NAD⁺ (CD38 and BST-1), we investigated the effects of extracellular cADPR on human hemopoietic progenitors (HP). Exposure of HP to 100 μM cADPR for 24 h induced a significant increase in colony output (P

Original language	English
Pages (from-to)	680-690
Number of pages	11
Journal	FASEB Journal
Volume	14
Issue number	5
Publication status	Published - 2000

Keywords

Bone marrow cells
Cytokine-like activity of cyclic ADP-ribose
Expansion of hemopoietic progenitors
Intracellular calcium homeostasis

ASJC Scopus subject areas

Agricultural and Biological Sciences (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
Biochemistry
Cell Biology

Cite this

Extracelluar cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. / Podestà, Marina; Zocchi, Elena; Pitto, Anna; Usai, Cesare; Franco, Luisa; Bruzzone, Santina; Guida, Lucrezia; Bacigalupo, Andrea; Scadden, David T.; Walseth, Timothy F.; De Flora, Antonio; Daga, Antonio.

In: FASEB Journal, Vol. 14, No. 5, 2000, p. 680-690.

Research output: Contribution to journal › Article › peer-review

Podestà, Marina ; Zocchi, Elena ; Pitto, Anna ; Usai, Cesare ; Franco, Luisa ; Bruzzone, Santina ; Guida, Lucrezia ; Bacigalupo, Andrea ; Scadden, David T. ; Walseth, Timothy F. ; De Flora, Antonio ; Daga, Antonio. / Extracelluar cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. In: FASEB Journal. 2000 ; Vol. 14, No. 5. pp. 680-690.

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AU - Podestà, Marina

AU - Zocchi, Elena

AU - Pitto, Anna

AU - Usai, Cesare

AU - Franco, Luisa

AU - Bruzzone, Santina

AU - Guida, Lucrezia

AU - Bacigalupo, Andrea

AU - Scadden, David T.

AU - Walseth, Timothy F.

AU - De Flora, Antonio

AU - Daga, Antonio

PY - 2000

Y1 - 2000

N2 - Cyclic ADP-ribose (cADPR) is a universal second messenger that regulates many calcium-related cellular events by releasing calcium from intracellular stores. Since these events include enhanced cell proliferation and since the bone marrow harbors both ectoenzymes that generate cADPR from NAD+ (CD38 and BST-1), we investigated the effects of extracellular cADPR on human hemopoietic progenitors (HP). Exposure of HP to 100 μM cADPR for 24 h induced a significant increase in colony output (P

AB - Cyclic ADP-ribose (cADPR) is a universal second messenger that regulates many calcium-related cellular events by releasing calcium from intracellular stores. Since these events include enhanced cell proliferation and since the bone marrow harbors both ectoenzymes that generate cADPR from NAD+ (CD38 and BST-1), we investigated the effects of extracellular cADPR on human hemopoietic progenitors (HP). Exposure of HP to 100 μM cADPR for 24 h induced a significant increase in colony output (P

KW - Bone marrow cells

KW - Cytokine-like activity of cyclic ADP-ribose

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KW - Intracellular calcium homeostasis

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Extracelluar cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors

Abstract

Keywords

ASJC Scopus subject areas

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