Extracellular and intracellular decoys in the tuning of inflammatory cytokines and Toll-like receptors: The new entry TIR8/SIGIRR

Alberto Mantovani, Massimo Locati, Nadia Polentarutti, Annunciata Vecchi, Cecilia Garlanda

Research output: Contribution to journalArticlepeer-review

Abstract

Following the identification of the interleukin (IL)-1 type II receptor as a prototypic decoy receptor, nonsignaling receptors with decoy functions have been identified for members of the IL-1/IL-18, tumor necrosis factor, IL-10, and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The type II IL-1 decoy receptor also acts as a dominant-negative molecule. Intracellular pathways of inhibition of IL-1 and Toll-like receptor (TLR) signaling have been identified. In particular, recent results suggest that the Toll/IL-1 receptor (TIR) family member TIR8, also known as single immunoglobulin IL-1-related receptor (SIGIRR), is a negative regulator of IL-1 and TLR signaling. Thus, extracellular and intracellular decoys tune the activation of members of the IL-1/TLR receptor family.

Original languageEnglish
Pages (from-to)738-742
Number of pages5
JournalJournal of Leukocyte Biology
Volume75
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Chemokines
  • Inflammation
  • Interleukin-1
  • Signaling

ASJC Scopus subject areas

  • Cell Biology

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