Extracellular ATP as a possible mediator of cell-mediated cytotoxicity

Francesco Di Virgilio, Paola Pizzo, Paola Zanovello, Vincenzo Bronte, Dino Collavo

Research output: Contribution to journalArticlepeer-review


Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells lyse target cells by a specialized mechanism that involves the release of soluble 'killer' mediators. While several possible mediators have been demonstrated, it is likely that others have yet to be identified. For more than two decades it has been known that exogenous ATP is lytic to many cell types. In this article Francesco Di Virgilio and colleagues propose that extracellular ATP may be a mediator of cytotoxic cell-dependent lysis.

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalImmunology Today
Issue numberC
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology


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