Abstract
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells lyse target cells by a specialized mechanism that involves the release of soluble 'killer' mediators. While several possible mediators have been demonstrated, it is likely that others have yet to be identified. For more than two decades it has been known that exogenous ATP is lytic to many cell types. In this article Francesco Di Virgilio and colleagues propose that extracellular ATP may be a mediator of cytotoxic cell-dependent lysis.
| Original language | English |
|---|---|
| Pages (from-to) | 274-277 |
| Number of pages | 4 |
| Journal | Immunology Today |
| Volume | 11 |
| Issue number | C |
| DOIs | |
| Publication status | Published - 1990 |
ASJC Scopus subject areas
- Immunology
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Cite this
Di Virgilio, F., Pizzo, P., Zanovello, P., Bronte, V., & Collavo, D. (1990). Extracellular ATP as a possible mediator of cell-mediated cytotoxicity. Immunology Today, 11(C), 274-277. https://doi.org/10.1016/0167-5699(90)90111-L