Extracellular ATP, P2 receptors, and inflammation

Francesco Di Virgilio, Davide Ferrari, Marco Idzko, Elisabeth Panther, Johannes Norgauer, Andrea La Sala, Giampiero Girolomoni

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past few years, P2 receptors have emerged as new potential players in the early phases of inflammation in their function of chemotactic receptors, triggers of proinflammatory cytokine release, and cytotoxic molecules. However, more recent data suggest that the role of P2 receptors in immunity is much more widespread and touches the very heart of the initiation of the immune response, i.e., antigen presentation by dendritic cells.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalDrug Development Research
Volume59
Issue number1
DOIs
Publication statusPublished - May 1 2003

Keywords

  • Allergy
  • Dendritic cells
  • EctoATPase
  • Immunity
  • Purinergic receptors

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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