Extracellular matrix: A matter of life and death

Stefano Marastoni, G. Ligresti, E. Lorenzon, Alfonso Colombatti, Maurizio Mongiat

Research output: Contribution to journalArticle

Abstract

Extracellular matrix (ECM) is an essential component of the stromal microenvironment both from a structural and a functional point of view. The ECM functions as a scaffold for tissue organization and regulates growth factors and chemokines availability thus contributing to maintain tissue homeostasis. Attachment of cells to ECM is essential to support cell survival, growth, and proliferation, and the lack of these interactions can trigger a type of cell death named anoikis. Several studies point out that alterations of ECM composition are often responsible of many pathological conditions such as cancer, of which it has been demonstrated to be occasionally the main promoter. ECM does not always represent a prosurvival stimulus; among the different array of ECM molecules a set of proteins can negatively affect cell viability and are thought to play an important role in tumor progression. For this reason attention has been focused on these molecules as potential tools or targets for therapy.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalConnective Tissue Research
Volume49
Issue number3-4
DOIs
Publication statusPublished - May 2008

Fingerprint

Extracellular Matrix
Tissue homeostasis
Cell Survival
Anoikis
Tissue Scaffolds
Molecules
Cell proliferation
Cell growth
Cell death
Chemokines
Tumors
Neoplasms
Intercellular Signaling Peptides and Proteins
Homeostasis
Cell Death
Cells
Cell Proliferation
Availability
Growth
Chemical analysis

Keywords

  • Apoptosis
  • Cell Survival
  • Extracellular Matrix (ECM)
  • Microenvironment

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Immunology
  • Nephrology
  • Orthopedics and Sports Medicine

Cite this

Marastoni, S., Ligresti, G., Lorenzon, E., Colombatti, A., & Mongiat, M. (2008). Extracellular matrix: A matter of life and death. Connective Tissue Research, 49(3-4), 203-206. https://doi.org/10.1080/03008200802143190

Extracellular matrix : A matter of life and death. / Marastoni, Stefano; Ligresti, G.; Lorenzon, E.; Colombatti, Alfonso; Mongiat, Maurizio.

In: Connective Tissue Research, Vol. 49, No. 3-4, 05.2008, p. 203-206.

Research output: Contribution to journalArticle

Marastoni, S, Ligresti, G, Lorenzon, E, Colombatti, A & Mongiat, M 2008, 'Extracellular matrix: A matter of life and death', Connective Tissue Research, vol. 49, no. 3-4, pp. 203-206. https://doi.org/10.1080/03008200802143190
Marastoni, Stefano ; Ligresti, G. ; Lorenzon, E. ; Colombatti, Alfonso ; Mongiat, Maurizio. / Extracellular matrix : A matter of life and death. In: Connective Tissue Research. 2008 ; Vol. 49, No. 3-4. pp. 203-206.
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