Extracellular matrix globules in renal oncocytoma

M. Guarino, E. Zuccoli, E. Garda, E. Cristofori, F. Pallotti, M. Nebuloni, F. Giordano

Research output: Contribution to journalArticle

Abstract

Extracellular hyaline globules resulting from abnormal accumulation of matrix components have been described in several pathological conditions, including renal tumors. We studied 16 renal oncocytomas and observed these bodies in 11 of them. In these tumors, they showed a homogeneous texture as well as roundish, smooth contours, and were easily detected in hematoxylin-eosin sections in five cases. PAS staining greatly facilitated the identification of globules in the remaining six cases, where they were fewer in number. Immunohistochemically, they appeared to be composed primarily of basement membrane material, being strongly reactive to antibodies for type IV collagen, laminin, and heparan sulphate proteoglycan. In addition, a weak immunoreactivity for type I and type III collagen, and fibronectin was observed in some cases, whereas no globule stained for tenascin. We also analyzed 89 renal cell carcinomas, and found somewhat similar bodies in 10 of them. However, they were more scanty in the latter tumors, and displayed a more irregular configuration with granular or smudged contours. We conclude that, although the mere presence of extracellular hyaline globules does not justify a distinction between renal oncocytoma and renal cell carcinoma, the detection of a large number of well-demarcated, roundish extracellular bodies with smooth contours suggests renal oncocytoma.

Original languageEnglish
Pages (from-to)245-252
Number of pages8
JournalPathology Research and Practice
Volume197
Issue number4
Publication statusPublished - 2001

Fingerprint

Extracellular Matrix
Hyalin
Renal Cell Carcinoma
Tenascin
Neoplasms
Heparan Sulfate Proteoglycans
Collagen Type III
Collagen Type IV
Laminin
Hematoxylin
Eosine Yellowish-(YS)
Collagen Type I
Fibronectins
Basement Membrane
Staining and Labeling
Kidney
Antibodies
Renal oncocytoma

Keywords

  • Extracellular matrix
  • Globules
  • Immunohistochemistry
  • Renal oncocytoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Guarino, M., Zuccoli, E., Garda, E., Cristofori, E., Pallotti, F., Nebuloni, M., & Giordano, F. (2001). Extracellular matrix globules in renal oncocytoma. Pathology Research and Practice, 197(4), 245-252.

Extracellular matrix globules in renal oncocytoma. / Guarino, M.; Zuccoli, E.; Garda, E.; Cristofori, E.; Pallotti, F.; Nebuloni, M.; Giordano, F.

In: Pathology Research and Practice, Vol. 197, No. 4, 2001, p. 245-252.

Research output: Contribution to journalArticle

Guarino, M, Zuccoli, E, Garda, E, Cristofori, E, Pallotti, F, Nebuloni, M & Giordano, F 2001, 'Extracellular matrix globules in renal oncocytoma', Pathology Research and Practice, vol. 197, no. 4, pp. 245-252.
Guarino M, Zuccoli E, Garda E, Cristofori E, Pallotti F, Nebuloni M et al. Extracellular matrix globules in renal oncocytoma. Pathology Research and Practice. 2001;197(4):245-252.
Guarino, M. ; Zuccoli, E. ; Garda, E. ; Cristofori, E. ; Pallotti, F. ; Nebuloni, M. ; Giordano, F. / Extracellular matrix globules in renal oncocytoma. In: Pathology Research and Practice. 2001 ; Vol. 197, No. 4. pp. 245-252.
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