Extracellular matrix: The gatekeeper of tumor angiogenesis

Maurizio Mongiat, Simone Buraschi, Eva Andreuzzi, Thomas Neill, Renato V. Iozzo

Research output: Contribution to journalReview articlepeer-review


The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

Original languageEnglish
Pages (from-to)1543-1555
Number of pages13
JournalBiochemical Society Transactions
Issue number5
Publication statusPublished - Oct 11 2019

ASJC Scopus subject areas

  • Biochemistry


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