TY - JOUR
T1 - Extracellular RNAs
T2 - A secret arm of immune system regulation
AU - De Candia, Paola
AU - De Rosa, Veronica
AU - Casiraghi, Maurizio
AU - Matarese, Giuseppe
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The immune system has evolved to protect multicellular organisms from the attack of a variety of pathogens. To exert this function efficiently, thesystemhas developed the capacity to coordinate the function of different cell types and the ability to down-modulate the response when the foreign attack is over. For decades, immunologists believed that these two characteristics were primarily related to cytokine/chemokine-based communication and cell-to-cell direct contact. More recently, it has been shown that immune cells also communicate by transferring regulatory RNAs, microRNAsin particular, from one cell to the other. Several studies have suggested a functional role of extracellular regulatory RNAs in cell-to-cellcommunicationin different cellular contexts. This minireview focuses on the potential role of extracellularRNAtransfer in the regulation of adaptive immune response, also contextualizing it in a broader field of what is known of cell-free RNAs in communication among different organisms in the evolutionary scale.
AB - The immune system has evolved to protect multicellular organisms from the attack of a variety of pathogens. To exert this function efficiently, thesystemhas developed the capacity to coordinate the function of different cell types and the ability to down-modulate the response when the foreign attack is over. For decades, immunologists believed that these two characteristics were primarily related to cytokine/chemokine-based communication and cell-to-cell direct contact. More recently, it has been shown that immune cells also communicate by transferring regulatory RNAs, microRNAsin particular, from one cell to the other. Several studies have suggested a functional role of extracellular regulatory RNAs in cell-to-cellcommunicationin different cellular contexts. This minireview focuses on the potential role of extracellularRNAtransfer in the regulation of adaptive immune response, also contextualizing it in a broader field of what is known of cell-free RNAs in communication among different organisms in the evolutionary scale.
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U2 - 10.1074/jbc.R115.708842
DO - 10.1074/jbc.R115.708842
M3 - Article
AN - SCOPUS:84964844037
VL - 291
SP - 7221
EP - 7228
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 14
ER -