Extracellular RNAs: A secret arm of immune system regulation

Paola De Candia, Veronica De Rosa, Maurizio Casiraghi, Giuseppe Matarese

Research output: Contribution to journalArticle

Abstract

The immune system has evolved to protect multicellular organisms from the attack of a variety of pathogens. To exert this function efficiently, thesystemhas developed the capacity to coordinate the function of different cell types and the ability to down-modulate the response when the foreign attack is over. For decades, immunologists believed that these two characteristics were primarily related to cytokine/chemokine-based communication and cell-to-cell direct contact. More recently, it has been shown that immune cells also communicate by transferring regulatory RNAs, microRNAsin particular, from one cell to the other. Several studies have suggested a functional role of extracellular regulatory RNAs in cell-to-cellcommunicationin different cellular contexts. This minireview focuses on the potential role of extracellularRNAtransfer in the regulation of adaptive immune response, also contextualizing it in a broader field of what is known of cell-free RNAs in communication among different organisms in the evolutionary scale.

Original languageEnglish
Pages (from-to)7221-7228
Number of pages8
JournalJournal of Biological Chemistry
Volume291
Issue number14
DOIs
Publication statusPublished - Apr 1 2016

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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