Extracellular superoxide dismutase is a thyroid differentiation marker down-regulated in cancer

Lilja E. Laatikainen, Maria D. Castellone, Aline Hebrant, Candice Hoste, Maria C. Cantisani, Juha P. Laurila, Giuliana Salvatore, Paolo Salerno, Fulvio Basolo, Johnny Näsman, Jacques E. Dumont, Massimo Santoro, Mikko O. Laukkanen

Research output: Contribution to journalArticlepeer-review


Reactive oxygen species, specifically hydrogen peroxide (H 2O2), have a significant role in hormone production in thyroid tissue. Although recent studies have demonstrated that dual oxidases are responsible for the H2O2 synthesis needed in thyroid hormone production, our data suggest a pivotal role for superoxide dismutase 3 (SOD3) as a major H2O2-producing enzyme. According to our results, Sod3 is highly expressed in normal thyroid, and becomes even more abundant in rat goiter models. We showed TSH-stimulated expression of Sod3 via phospholipase C-Ca2+ and cAMP-protein kinase A, a pathway that might be disrupted in thyroid cancer. In line with this finding, we demonstrated an oncogene-dependent decrease in Sod3 mRNA expression synthesis in thyroid cancer cell models that corresponded to a similar decrease in clinical patient samples, suggesting that SOD3 could be used as a differentiation marker in thyroid cancer. Finally, the functional analysis in thyroid models indicated a moderate role for SOD3 in regulating normal thyroid cell proliferation being in line with our previous observations.

Original languageEnglish
Pages (from-to)785-796
Number of pages12
JournalEndocrine-Related Cancer
Issue number3
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism


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