Extracellular vesicles as natural, safe and efficient drug delivery systems

Federico Villa, Rodolfo Quarto, Roberta Tasso

Research output: Contribution to journalReview article

Abstract

Extracellular vesicles (EVs) are particles naturally released from cells, delimited by a lipid bilayer, carrying functionally active biological molecules. In addition to their physiological role in cellular communication, the interest of the scientific community has recently turned to the use of EVs as vehicles for delivering therapeutic molecules. Several attempts are being made to ameliorate drug encapsulation and targeting, but these efforts are thwarted if the starting material does not meet stringent quality criteria. Here, we take a step back to the sources and isolation procedures that could guarantee significant improvements in the purification of EVs to be used as drug carriers, highlighting the advantages and shortcomings of each approach.

Original languageEnglish
Article number557
JournalPharmaceutics
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Drug carriers
  • Extracellular vesicles
  • Isolation methods

ASJC Scopus subject areas

  • Pharmaceutical Science

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