Extracellular vesicles circulating in young organisms promote healthy longevity

Francesco Prattichizzo, Angelica Giuliani, Jacopo Sabbatinelli, Emanuela Mensà, Valeria De Nigris, Lucia La Sala, Paola de Candia, Fabiola Olivieri, Antonio Ceriello

Research output: Contribution to journalLetter

Abstract

Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far. Novel results suggest that extracellular vesicles isolated from plasma of young mice increase lifespan in old mice. Here we integrate these findings in a larger framework, advancing the hypothesis that circulating vesicles may mediate the beneficial effect of a young milieu on ageing.

Original languageEnglish
Article number1656044
JournalJournal of Extracellular Vesicles
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • ageing
  • eNAMPT
  • Extracellular vesicles
  • inflammaging
  • lifespan
  • miRNAs
  • NAD+
  • physical activity
  • SASP
  • senescence
  • SIRT1

ASJC Scopus subject areas

  • Histology
  • Cell Biology

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