Extracellular vesicles derived from mesenchymal cells: Perspective treatment for cutaneous wound healing in pediatrics

Gloria Pelizzo, Maria Antonietta Avanzini, Antonia Icaro Cornaglia, Annalisa De Silvestri, Melissa Mantelli, Paola Travaglino, Stefania Croce, Piero Romano, Luigi Avolio, Giulio Iacob, Massimo Dominici, Valeria Calcaterra

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model. Methods: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation. Results: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036). Conclusion: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalRegenerative Medicine
Volume13
Issue number4
DOIs
Publication statusPublished - Jun 1 2018

Keywords

  • animal model
  • children
  • cutaneous wound repair
  • extracellular vesicles
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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