Extracellular vesicles derived from mesenchymal cells: Perspective treatment for cutaneous wound healing in pediatrics

Gloria Pelizzo, Maria Antonietta Avanzini, Antonia Icaro Cornaglia, Annalisa De Silvestri, Melissa Mantelli, Paola Travaglino, Stefania Croce, Piero Romano, Luigi Avolio, Giulio Iacob, Massimo Dominici, Valeria Calcaterra

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model. Methods: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation. Results: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036). Conclusion: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalRegenerative Medicine
Volume13
Issue number4
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Pediatrics
Stem cells
Wound Healing
Skin
Mesenchymal Stromal Cells
Therapeutics
Wounds and Injuries
Restoration
Extracellular Vesicles
Intradermal Injections
Bone
Animals
Repair
Regenerative Medicine
Cells
Tissue
Bone Marrow Cells
Stem Cells
Rabbits
Injections

Keywords

  • animal model
  • children
  • cutaneous wound repair
  • extracellular vesicles
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

Cite this

Extracellular vesicles derived from mesenchymal cells : Perspective treatment for cutaneous wound healing in pediatrics. / Pelizzo, Gloria; Avanzini, Maria Antonietta; Icaro Cornaglia, Antonia; De Silvestri, Annalisa; Mantelli, Melissa; Travaglino, Paola; Croce, Stefania; Romano, Piero; Avolio, Luigi; Iacob, Giulio; Dominici, Massimo; Calcaterra, Valeria.

In: Regenerative Medicine, Vol. 13, No. 4, 01.06.2018, p. 385-394.

Research output: Contribution to journalArticle

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AU - Pelizzo, Gloria

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AU - Icaro Cornaglia, Antonia

AU - De Silvestri, Annalisa

AU - Mantelli, Melissa

AU - Travaglino, Paola

AU - Croce, Stefania

AU - Romano, Piero

AU - Avolio, Luigi

AU - Iacob, Giulio

AU - Dominici, Massimo

AU - Calcaterra, Valeria

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