TY - JOUR
T1 - Extracellular Vesicles
T2 - Footprints of environmental exposures in the aging process?
AU - Monti, Paola
AU - Solazzo, Giulia
AU - Ferrari, Luca
AU - Bollati, Valentina
N1 - Funding Information:
GS was supported by the Environmental Sciences PhD Fellowship, University of Milan, Italy. PM was supported by the Public Health Sciences PhD Fellowship, University of Milan, Italy.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2021
Y1 - 2021
N2 - Purpose of the review: Extracellular vesicles (EVs) are nano-sized lipid particles that participate in intercellular signaling through the trafficking of bioactive molecules from parental cells to recipient ones. This well-orchestrated communication system is crucial for the organism to respond to external cues in a coordinated manner; indeed, environmental and lifestyle exposures can modify both EV number and content, with consequences on cellular metabolism and homeostasis. In particular, a growing body of evidence suggests that exposome-induced changes in EV profile could regulate the aging process, both at the cellular and organismal levels. Here, we provide an overview of the role played by ambient-induced EVs on aging and age-related diseases. Among the several environmental factors that can affect the communication network operated by EVs, we focused on air pollution, ultraviolet light, diet, and physical exercise. Moreover, we performed a miRNA target analysis, to support the role of EV-miRNA emerging from the literature in the context of aging. Recent findings: The overall emerging picture strongly supports a key regulatory role for EVs at the interface between external stimuli and cellular/organismal aging, thus providing novel insights into the molecular mechanisms linking a “healthy exposome” to well-being in old age. In addition, this knowledge will pave the way for research aimed at developing innovative antiaging strategies based on EVs.
AB - Purpose of the review: Extracellular vesicles (EVs) are nano-sized lipid particles that participate in intercellular signaling through the trafficking of bioactive molecules from parental cells to recipient ones. This well-orchestrated communication system is crucial for the organism to respond to external cues in a coordinated manner; indeed, environmental and lifestyle exposures can modify both EV number and content, with consequences on cellular metabolism and homeostasis. In particular, a growing body of evidence suggests that exposome-induced changes in EV profile could regulate the aging process, both at the cellular and organismal levels. Here, we provide an overview of the role played by ambient-induced EVs on aging and age-related diseases. Among the several environmental factors that can affect the communication network operated by EVs, we focused on air pollution, ultraviolet light, diet, and physical exercise. Moreover, we performed a miRNA target analysis, to support the role of EV-miRNA emerging from the literature in the context of aging. Recent findings: The overall emerging picture strongly supports a key regulatory role for EVs at the interface between external stimuli and cellular/organismal aging, thus providing novel insights into the molecular mechanisms linking a “healthy exposome” to well-being in old age. In addition, this knowledge will pave the way for research aimed at developing innovative antiaging strategies based on EVs.
KW - aging
KW - air pollution
KW - diet
KW - Extracellular vesicles
KW - physical exercise
KW - ultraviolet exposure
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U2 - 10.1007/s40572-021-00327-3
DO - 10.1007/s40572-021-00327-3
M3 - Review article
AN - SCOPUS:85118548359
VL - 8
SP - 309
EP - 322
JO - Current environmental health reports
JF - Current environmental health reports
SN - 2196-5412
IS - 4
ER -