Extracellular vesicles in Alzheimer’s disease: Friends or foes? focus on Aβ-vesicle interaction

Pooja Joshi, Luisa Benussi, Roberto Furlan, Roberta Ghidoni, Claudia Verderio

Research output: Contribution to journalArticlepeer-review

Abstract

The intercellular transfer of amyloid-β (Aβ) and tau proteins has received increasing attention in Alzheimer’s disease (AD). Among other transfer modes, Aβ and tau dissemination has been suggested to occur through release of Extracellular Vesicles (EVs), which may facilitate delivery of pathogenic proteins over large distances. Recent evidence indicates that EVs carry on their surface, specific molecules which bind to extracellular Aβ, opening the possibility that EVs may also influence Aβ assembly and synaptotoxicity. In this review we focus on studies which investigated the impact of EVs in Aβ-mediated neurodegeneration and showed either detrimental or protective role for EVs in the pathology.

Original languageEnglish
Pages (from-to)4800-4813
Number of pages14
JournalInternational Journal of Molecular Sciences
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 3 2015

Keywords

  • Aβ assembly
  • Extracellular Vesicles
  • Neurodegeneration
  • Oligomeric Aβ
  • Toxcicity

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

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