Extracellular Vesicles in Human Oogenesis and Implantation

Francesca Andronico, Rosalia Battaglia, Marco Ragusa, Davide Barbagallo, Michele Purrello, Cinzia Di Pietro

Research output: Contribution to journalReview article

Abstract

Reproduction, the ability to generate offspring, represents one of the most important biological processes, being essential for the conservation of the species. In mammals, it involves different cell types, tissues and organs, which, by several signaling molecules, coordinate the different events such as gametogenesis, fertilization and embryo development. In the last few years, the role of Extracellular Vesicles, as mediators of cell communication, has been investigated in every phase of these complex processes. Microvesicles and exosomes, identified in the fluid of ovarian follicles during egg maturation, are involved in communication between the developing oocyte and the somatic follicular cells. More recently, it has been demonstrated that, during implantation, Extracellular Vesicles could participate in the complex dialog between the embryo and maternal tissues. In this review, we will focus our attention on extracellular vesicles and their cargo in human female reproduction, mainly underlining the involvement of microRNAs in intercellular communication during the several phases of the reproductive process.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number9
DOIs
Publication statusPublished - May 1 2019

Fingerprint

Oogenesis
implantation
communication
embryos
Reproduction
Communication
cells
Tissue
Exosomes
gametocytes
Gametogenesis
Biological Phenomena
fertilization
mammals
Aptitude
Mammals
cargo
Ovarian Follicle
eggs
MicroRNAs

Keywords

  • Blastocyst
  • Endometrium
  • Exosomes
  • Extracellular vesicles
  • MicroRNAs
  • Microvesicles
  • Oocyte

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Extracellular Vesicles in Human Oogenesis and Implantation. / Andronico, Francesca; Battaglia, Rosalia; Ragusa, Marco; Barbagallo, Davide; Purrello, Michele; Di Pietro, Cinzia.

In: International Journal of Molecular Sciences, Vol. 20, No. 9, 01.05.2019.

Research output: Contribution to journalReview article

Andronico, Francesca ; Battaglia, Rosalia ; Ragusa, Marco ; Barbagallo, Davide ; Purrello, Michele ; Di Pietro, Cinzia. / Extracellular Vesicles in Human Oogenesis and Implantation. In: International Journal of Molecular Sciences. 2019 ; Vol. 20, No. 9.
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