Extracellular Vesicles in Multiple Sclerosis: Role in the Pathogenesis and Potential Usefulness as Biomarkers and Therapeutic Tools

Marianna D'Anca, Chiara Fenoglio, Francesca Romana Buccellato, Caterina Visconte, Daniela Galimberti, Elio Scarpini

Research output: Contribution to journalReview articlepeer-review

Abstract

Although extracellular vesicles (EVs) were initially relegated to a waste disposal role, nowadays, they have gained multiple fundamental functions working as messengers in intercellular communication as well as exerting active roles in physiological and pathological processes. Accumulating evidence proves the involvement of EVs in many diseases, including those of the central nervous system (CNS), such as multiple sclerosis (MS). Indeed, these membrane-bound particles, produced in any type of cell, carry and release a vast range of bioactive molecules (nucleic acids, proteins, and lipids), conferring genotypic and phenotypic changes to the recipient cell. This means that not only EVs per se but their content, especially, could reveal new candidate disease biomarkers and/or therapeutic agents. This review is intended to provide an overview regarding current knowledge about EVs' involvement in MS, analyzing the potential versatility of EVs as a new therapeutic tool and source of biomarkers.

Original languageEnglish
Article number1733
JournalCells
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 8 2021

Keywords

  • biomarkers
  • extracellular vesicles
  • extracellular vesicles cargo
  • microRNAs
  • multiple sclerosis
  • therapeutic approach

ASJC Scopus subject areas

  • Medicine(all)

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