TY - JOUR
T1 - Extracellular Vesicles in Multiple Sclerosis
T2 - Role in the Pathogenesis and Potential Usefulness as Biomarkers and Therapeutic Tools
AU - D'Anca, Marianna
AU - Fenoglio, Chiara
AU - Buccellato, Francesca Romana
AU - Visconte, Caterina
AU - Galimberti, Daniela
AU - Scarpini, Elio
PY - 2021/7/8
Y1 - 2021/7/8
N2 - Although extracellular vesicles (EVs) were initially relegated to a waste disposal role, nowadays, they have gained multiple fundamental functions working as messengers in intercellular communication as well as exerting active roles in physiological and pathological processes. Accumulating evidence proves the involvement of EVs in many diseases, including those of the central nervous system (CNS), such as multiple sclerosis (MS). Indeed, these membrane-bound particles, produced in any type of cell, carry and release a vast range of bioactive molecules (nucleic acids, proteins, and lipids), conferring genotypic and phenotypic changes to the recipient cell. This means that not only EVs per se but their content, especially, could reveal new candidate disease biomarkers and/or therapeutic agents. This review is intended to provide an overview regarding current knowledge about EVs' involvement in MS, analyzing the potential versatility of EVs as a new therapeutic tool and source of biomarkers.
AB - Although extracellular vesicles (EVs) were initially relegated to a waste disposal role, nowadays, they have gained multiple fundamental functions working as messengers in intercellular communication as well as exerting active roles in physiological and pathological processes. Accumulating evidence proves the involvement of EVs in many diseases, including those of the central nervous system (CNS), such as multiple sclerosis (MS). Indeed, these membrane-bound particles, produced in any type of cell, carry and release a vast range of bioactive molecules (nucleic acids, proteins, and lipids), conferring genotypic and phenotypic changes to the recipient cell. This means that not only EVs per se but their content, especially, could reveal new candidate disease biomarkers and/or therapeutic agents. This review is intended to provide an overview regarding current knowledge about EVs' involvement in MS, analyzing the potential versatility of EVs as a new therapeutic tool and source of biomarkers.
KW - biomarkers
KW - extracellular vesicles
KW - extracellular vesicles cargo
KW - microRNAs
KW - multiple sclerosis
KW - therapeutic approach
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U2 - 10.3390/cells10071733
DO - 10.3390/cells10071733
M3 - Review article
C2 - 34359903
AN - SCOPUS:85114082959
VL - 10
JO - Cells
JF - Cells
SN - 2073-4409
IS - 7
M1 - 1733
ER -