TY - JOUR
T1 - Extracellular Vesicles Loaded miRNAs as Potential Modulators Shared Between Glioblastoma, and Parkinson’s and Alzheimer’s Diseases
AU - Thomas, Laura
AU - Florio, Tullio
AU - Perez-Castro, Carolina
N1 - Funding Information:
Authors thank Dr. Eduardo Arzt and Dr. Lucas Pontel (IBioBA-MPSM-CONICET, Buenos Aires, Argentina) and Dr. Ken Kobayashi (IBBEA-CONICET, FCEN, UBA, Argentina) for their critical reading. Authors also would like to thank Agencia Nacional de Promoci?n Cient?fica y T?cnica, Argentina (ANPCyT), Consejo Nacional de Investigaciones Cient?ficas y T?cnicas (CONICET), and FOCEM-Mercosur (COF 03/11).
Publisher Copyright:
© Copyright © 2020 Thomas, Florio and Perez-Castro.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/4
Y1 - 2020/11/4
N2 - Glioblastoma (GBM) is the deadliest brain tumor. Its poor prognosis is due to cell heterogeneity, invasiveness, and high vascularization that impede an efficient therapeutic approach. In the past few years, several molecular links connecting GBM to neurodegenerative diseases (NDDs) were identified at preclinical and clinical level. In particular, giving the increasing critical role that epigenetic alterations play in both GBM and NDDs, we deeply analyzed the role of miRNAs, small non-coding RNAs acting epigenetic modulators in several key biological processes. Specific miRNAs, transported by extracellular vesicles (EVs), act as intercellular communication signals in both diseases. In this way, miRNA-loaded EVs modulate GBM tumorigenesis, as they spread oncogenic signaling within brain parenchyma, and control the aggregation of neurotoxic protein (Tau, Aβ-amyloid peptide, and α-synuclein) in NDDs. In this review, we highlight the most promising miRNAs linking GBM and NDDs playing a significant pathogenic role in both diseases.
AB - Glioblastoma (GBM) is the deadliest brain tumor. Its poor prognosis is due to cell heterogeneity, invasiveness, and high vascularization that impede an efficient therapeutic approach. In the past few years, several molecular links connecting GBM to neurodegenerative diseases (NDDs) were identified at preclinical and clinical level. In particular, giving the increasing critical role that epigenetic alterations play in both GBM and NDDs, we deeply analyzed the role of miRNAs, small non-coding RNAs acting epigenetic modulators in several key biological processes. Specific miRNAs, transported by extracellular vesicles (EVs), act as intercellular communication signals in both diseases. In this way, miRNA-loaded EVs modulate GBM tumorigenesis, as they spread oncogenic signaling within brain parenchyma, and control the aggregation of neurotoxic protein (Tau, Aβ-amyloid peptide, and α-synuclein) in NDDs. In this review, we highlight the most promising miRNAs linking GBM and NDDs playing a significant pathogenic role in both diseases.
KW - Alzheimer’s disease
KW - extracellular vesicles
KW - glioblastoma
KW - miRNAs
KW - Parkinson’s disease
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U2 - 10.3389/fncel.2020.590034
DO - 10.3389/fncel.2020.590034
M3 - Review article
AN - SCOPUS:85096162388
VL - 14
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
SN - 1662-5102
M1 - 590034
ER -