Extracellular Vesicles Loaded miRNAs as Potential Modulators Shared Between Glioblastoma, and Parkinson’s and Alzheimer’s Diseases

Laura Thomas, Tullio Florio, Carolina Perez-Castro

Research output: Contribution to journalReview articlepeer-review

Abstract

Glioblastoma (GBM) is the deadliest brain tumor. Its poor prognosis is due to cell heterogeneity, invasiveness, and high vascularization that impede an efficient therapeutic approach. In the past few years, several molecular links connecting GBM to neurodegenerative diseases (NDDs) were identified at preclinical and clinical level. In particular, giving the increasing critical role that epigenetic alterations play in both GBM and NDDs, we deeply analyzed the role of miRNAs, small non-coding RNAs acting epigenetic modulators in several key biological processes. Specific miRNAs, transported by extracellular vesicles (EVs), act as intercellular communication signals in both diseases. In this way, miRNA-loaded EVs modulate GBM tumorigenesis, as they spread oncogenic signaling within brain parenchyma, and control the aggregation of neurotoxic protein (Tau, Aβ-amyloid peptide, and α-synuclein) in NDDs. In this review, we highlight the most promising miRNAs linking GBM and NDDs playing a significant pathogenic role in both diseases.

Original languageEnglish
Article number590034
JournalFrontiers in Cellular Neuroscience
Volume14
DOIs
Publication statusPublished - Nov 4 2020

Keywords

  • Alzheimer’s disease
  • extracellular vesicles
  • glioblastoma
  • miRNAs
  • Parkinson’s disease

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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