Extracranial metastases in secondary glioblastoma multiforme: a case report

Jessica Rossi, Lucia Giaccherini, Francesco Cavallieri, Manuela Napoli, Claudio Moratti, Elisabetta Froio, Silvia Serra, Alessandro Fraternali, Reza Ghadirpour, Salvatore Cozzi, Patrizia Ciammella, Corrado Iaccarino, Rosario Pascarella, Franco Valzania, Anna Pisanello

Research output: Contribution to journalArticlepeer-review


Background: Glioblastoma (GBM) is known for its devastating intracranial infiltration and its unfavorable prognosis, while extracranial involvement is a very rare event, more commonly attributed to IDH wild-type (primary) GBM evolution. Case presentation: We present a case of a young woman with a World Health Organization (WHO) grade II Astrocytoma evolved to WHO grade IV IDH mutant glioblastoma, with subsequent development of lymphatic and bone metastases, despite the favorable biomolecular pattern and the stability of the primary brain lesion. Conclusions: Our case highlights that grade II Astrocytoma may evolve to a GBM and rarely lead to a secondary metastatic diffusion, which can progress quite rapidly; any symptoms referable to a possible systemic involvement should be carefully investigated.

Original languageEnglish
Article number382
JournalBMC Neurology
Issue number1
Publication statusPublished - Dec 1 2020


  • Extracranial
  • Glioblastoma
  • IDH mutant
  • Metastases
  • Secondary

ASJC Scopus subject areas

  • Clinical Neurology


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