In radiation therapy the dose (daily dose, total dose, dose-rate), the volume (GTV, CTV, PTV, TV), and the treatment time (conventional or not conventional) constitute the basic parameters for the radiotherapy effectiveness. Accelerated hypofractionation is less investigated than other fractionation schedules. However its application on small tumors, i. e. through HDR BT and radiosurgery, obtained in comparable oncological situations better results than conventional treatments. Accelerated hypofractionation also improves the efficiency of the radiotherapy departments. Since 1990 the clinical use of the Policentric Multiple Arc (PAM) technique started on. This technique allows us to reproduce dose distributions similar to those of the brachiterapy treatments with linear sources (inhomogeneous dose that increases inside the tumor and that quickly decreases outside the target). This technique allowed accelerated hypofractionated schedules also in the treatment of large and very large tumors. In this presentation we describe the possibility to reproduce and to ameliorate the main characteristics of the PMA technique using either IMRTor IMAT techniques. Some examples of clinical application on extracranial cancers are discussed.
|Translated title of the contribution||Extracranial tumors and accelerated hypofractionation of the dose|
|Number of pages||8|
|Publication status||Published - Mar 2007|
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