Extradural Motor Cortex Stimulation might improve episodic and working memory in patients with Parkinson's disease

Carla Piano, Marco Ciavarro, Francesco Bove, Daniela Di Giuda, Fabrizio Cocciolillo, Anna Rita Bentivoglio, Beatrice Cioni, Tommaso Tufo, Paolo Calabresi, Antonio Daniele

Research output: Contribution to journalArticlepeer-review

Abstract

Electric Extradural Motor Cortex Stimulation (EMCS) is a neurosurgical procedure suggested for treatment of patients with advanced Parkinson's disease (PD). We report two PD patients treated by EMCS, who experienced worsening of motor symptoms and cognition 5 years after surgery, when EMCS batteries became discharged. One month after EMCS restoration, they experienced a subjective improvement of motor symptoms and cognition. Neuropsychological assessments were carried out before replacement of batteries (off-EMCS condition) and 6 months afterward (on-EMCS condition). As compared to off-EMCS condition, in on-EMCS condition both patients showed an improvement on tasks of verbal episodic memory and backward spatial short-term/working memory task, and a decline on tasks of selective visual attention and forward spatial short-term memory. These findings suggest that in PD patients EMCS may induce slight beneficial effects on motor symptoms and cognitive processes involved in verbal episodic memory and in active manipulation of information stored in working memory.

Original languageEnglish
Pages (from-to)26
Journalnpj Parkinson's Disease
Volume6
DOIs
Publication statusPublished - 2020

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