Extrahepatic disorders of HCV infection: A distinct entity of B-cell neoplasia?

Massimo Libra, Jerry Polesel, Alessia Erika Russo, Vallì De Re, Diana Cinà, Diego Serraino, Ferdinando Nicoletti, Demetrios A. Spandidos, Franca Stivala, Renato Talamini

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Some infectious agents have been associated with B-cell lymphoma development. In the last decades, it has been demonstrated that patients infected by hepatitis C virus (HCV) are more likely to develop B-cell non-Hodgkin's lymphoma (NHL) than those uninfected. The prevalence of HCV-infection among NHL patients is reported in this review of all Italian studies on NHL and HCV infection, both case-control and case series. From 18 studies, the prevalence of anti-HCV antibodies in 2736 NHL patients was 19.7% (range: 8.3-37.1%). The association of HCV-infection with each NHL histotype in case-control studies is discussed. Molecular mechanisms by which HCV infection promotes B-cell NHL development is also explored and indicate that HCV-associated lymphomas may be a distinct entity. Clarification of these mechanisms may improve diagnosis, classification and therapy of this subset of NHL. Finally, treatment of HCV-positive patients with lymphoproliferative disorders are herein summarized and further support the notion that HCV infection contributes to the development of these pathologic conditions.

Original languageEnglish
Pages (from-to)1331-1340
Number of pages10
JournalInternational Journal of Oncology
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2010

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Virus Diseases
Hepacivirus
Non-Hodgkin's Lymphoma
B-Lymphocytes
Neoplasms
B-Cell Lymphoma
Hepatitis C Antibodies
Lymphoproliferative Disorders
Case-Control Studies
Lymphoma
Cross-Sectional Studies
Therapeutics

Keywords

  • Casecontrol studies
  • Gene alterations
  • Hepatitis C virus
  • Non-Hodgkin's lymphoma
  • VDJ rearrangement

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Extrahepatic disorders of HCV infection : A distinct entity of B-cell neoplasia? / Libra, Massimo; Polesel, Jerry; Russo, Alessia Erika; De Re, Vallì; Cinà, Diana; Serraino, Diego; Nicoletti, Ferdinando; Spandidos, Demetrios A.; Stivala, Franca; Talamini, Renato.

In: International Journal of Oncology, Vol. 36, No. 6, 06.2010, p. 1331-1340.

Research output: Contribution to journalArticle

Libra, M, Polesel, J, Russo, AE, De Re, V, Cinà, D, Serraino, D, Nicoletti, F, Spandidos, DA, Stivala, F & Talamini, R 2010, 'Extrahepatic disorders of HCV infection: A distinct entity of B-cell neoplasia?', International Journal of Oncology, vol. 36, no. 6, pp. 1331-1340. https://doi.org/10.3892/ijo-00000618
Libra, Massimo ; Polesel, Jerry ; Russo, Alessia Erika ; De Re, Vallì ; Cinà, Diana ; Serraino, Diego ; Nicoletti, Ferdinando ; Spandidos, Demetrios A. ; Stivala, Franca ; Talamini, Renato. / Extrahepatic disorders of HCV infection : A distinct entity of B-cell neoplasia?. In: International Journal of Oncology. 2010 ; Vol. 36, No. 6. pp. 1331-1340.
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