Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor

Emma Diaz De Leon, Maria Luisa Carcangiu, Victor G. Prieto, Peter A. McCue, James L. Burchette, Gia To, Brent A. Norris, Albert J. Kovatich, Ramon L. Sanchez, Hannah R. Krigman, Zoran Gatalica

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Extramammary Paget disease (EPD) is an uncommon cutaneous malignant neoplasm that arises in areas rich in apocrine glands (perineum, vulva, and axilla). Apocrine gland origin or apocrine differentiation of cells of EPD has been suggested. Estrogen, progesterone, and androgen hormone receptors have been reported to exhibit a characteristic pattern of expression in mammary apocrine type carcinomas; however, their expression in EPD has not been elucidated fully. By using immunohistochemical methods, we studied the expression of steroid receptors in EPD on formalin-fixed paraffin-embedded tissue samples from 28 patients with EPD without associated visceral malignant neoplasms or adnexal carcinoma. Androgen receptor (AR) was identified in 15 of 28 cases. The proportion of AR-positive cells varied from 1% to more than 75%; 8 cases expressed AR in more than 10% of cells. Strong AR expression also was seen fit the invasive carcinoma arising from 1 case of EPD. All cases lacked immunohistochemically detectable estrogen and progesterone receptors. The immunophenotype characteristic of apocrine carcinomas (AR-positive, estrogen receptor-negative, progesterone receptor- negative) was seen in a substantial proportion of EPD cases. Results suggest that AR expression is a factor in pathogenesis of EPD. This may be important for the therapy of recurrent or invasive disease.

Original languageEnglish
Pages (from-to)572-575
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume113
Issue number4
Publication statusPublished - 2000

Fingerprint

Extramammary Paget's Disease
Androgen Receptors
Progesterone Receptors
Estrogen Receptors
Apocrine Glands
Carcinoma
Perineum
Axilla
Vulva
Steroid Receptors
Skin Neoplasms
Paraffin
Formaldehyde
Progesterone
Cell Differentiation
Estrogens
Hormones
Breast Neoplasms

Keywords

  • Extramammary Paget disease
  • Immunohistochemistry
  • Skin neoplasms
  • Steroid hormone receptors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

De Leon, E. D., Carcangiu, M. L., Prieto, V. G., McCue, P. A., Burchette, J. L., To, G., ... Gatalica, Z. (2000). Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor. American Journal of Clinical Pathology, 113(4), 572-575.

Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor. / De Leon, Emma Diaz; Carcangiu, Maria Luisa; Prieto, Victor G.; McCue, Peter A.; Burchette, James L.; To, Gia; Norris, Brent A.; Kovatich, Albert J.; Sanchez, Ramon L.; Krigman, Hannah R.; Gatalica, Zoran.

In: American Journal of Clinical Pathology, Vol. 113, No. 4, 2000, p. 572-575.

Research output: Contribution to journalArticle

De Leon, ED, Carcangiu, ML, Prieto, VG, McCue, PA, Burchette, JL, To, G, Norris, BA, Kovatich, AJ, Sanchez, RL, Krigman, HR & Gatalica, Z 2000, 'Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor', American Journal of Clinical Pathology, vol. 113, no. 4, pp. 572-575.
De Leon, Emma Diaz ; Carcangiu, Maria Luisa ; Prieto, Victor G. ; McCue, Peter A. ; Burchette, James L. ; To, Gia ; Norris, Brent A. ; Kovatich, Albert J. ; Sanchez, Ramon L. ; Krigman, Hannah R. ; Gatalica, Zoran. / Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor. In: American Journal of Clinical Pathology. 2000 ; Vol. 113, No. 4. pp. 572-575.
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