Extramedullary involvement in patients with acute promyelocytic leukemia: A report of seven cases

Vincenzo Liso, Giorgina Specchia, Enrico M. Pogliani, Gaetano Palumbo, Donata Mininni, Vincenzo Rossi, Elisabetta Teruzzi, Anna Mestice, Maria Rosaria Coppi, Andrea Biondi

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Abstract

BACKGROUND. Extramedullary involvement is only occasionally observed in patients with acute promyelocytic leukemia (APL) but has been said to occur more frequently after treatment with all-trans retinoic acid (ATRA) than after treatment with cytotoxic drugs. In the literature, 37 well-documented cases have been reported. METHODS. The authors report 7 patients with extramedullary APL documented by cytologic, phenotypic, and molecular analyses among 120 adult APL patients referred to two different institutions during a period of 9 years. RESULTS. In this APL series, extramedullary disease (EMD) occurred in 7 of 120 cases (5.8%). The extramedullary sites were the skin in five patients, the central nervous system in one, and the lymph nodes in one. Molecular analysis of the PML/RARα rearrangement was performed on four samples of skin and one of CSF; all patients exhibited the same molecular pattern in the bone marrow (BM) and EMD sites. Of 120 patients, 61 were treated with ATRA plus chemotherapy and 59 with chemotherapy alone. Relapses were observed in 38 patients, 6 of whom had EMD; 1 patient had developed EMD at the onset of APL. Of the relapsed EMD cases, 2 of 61 patients had received ATRA plus chemotherapy and 4 of 59 had received chemotherapy alone. CONCLUSIONS. There is some controversy as to whether treatment of APL with ATRA may predispose patients to the development of extramedullary relapse. The data from this study do not contain evidence that EMD may occur more frequently in APL patients treated with ATRA.

Original languageEnglish
Pages (from-to)1522-1528
Number of pages7
JournalCancer
Volume83
Issue number8
DOIs
Publication statusPublished - Oct 15 1998

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Keywords

  • Acute promyelocytic leukemia
  • All-trans retinoic acid
  • Chemotherapy
  • Extramedullary disease

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Liso, V., Specchia, G., Pogliani, E. M., Palumbo, G., Mininni, D., Rossi, V., Teruzzi, E., Mestice, A., Coppi, M. R., & Biondi, A. (1998). Extramedullary involvement in patients with acute promyelocytic leukemia: A report of seven cases. Cancer, 83(8), 1522-1528. https://doi.org/10.1002/(SICI)1097-0142(19981015)83:8<1522::AID-CNCR6>3.0.CO;2-4