Extranodal lymphomas associated with hepatitis C virus infection

Valeria Ascoli, Francesco Lo Coco, Marco Artini, Massimo Levrero, Maurizio Martelli, Francesco Negro

Research output: Contribution to journalArticle

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Abstract

Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma. We describe eight cases of B-cell extranodal non-Hodgkin's lymphoma occurring during the course of chronic HCV-related hepatic disease (low- grade of mucosa-associated lymphoid tissue [MALT]-type; diffuse large cell; Burkitt; diffuse small cell). Some were localized to the liver (2), liver and spleen (1), spleen (1), peritoneal cavity (1), parotid gland (1); others manifested in the nasopharynx (1) and eyelid (1) but were accompanied by nodal disease. Four lymphomatous specimens available for molecular analysis exhibited clonal immunoglobulin gene rearrangements, lacked bcl-2, bcl-6, c- myc genes and p53 alterations, and did not contain replicative intermediate HCV RNA, as documented by a strand-specific reverse transcriptase-polymerase chain reaction. Low levels of positive-strand HCV RNA were detected in a single hepatic lymphoma, suggesting the presence of the virus in residual hepatocytes. The antigen-driven properties of HCV-associated B-cell malignant neoplasms may be considered for hepatic MALT-type lymphoma, which probably originated from lymphoid tissue acquired during long-standing HCV infection.

Original languageEnglish
Pages (from-to)600-609
Number of pages10
JournalAmerican Journal of Clinical Pathology
Volume109
Issue number5
Publication statusPublished - 1998

Fingerprint

Virus Diseases
Hepacivirus
Lymphoma
Liver
Lymphoid Tissue
Non-Hodgkin's Lymphoma
B-Lymphocytes
Spleen
RNA
Marginal Zone B-Cell Lymphoma
Immunoglobulin Genes
myc Genes
Nasopharynx
Gene Rearrangement
Parotid Gland
Peritoneal Cavity
Chronic Hepatitis C
Eyelids
Reverse Transcriptase Polymerase Chain Reaction
Hepatocytes

Keywords

  • B cell
  • HCV genotype
  • Immunoglobulin heavy-chain rearrangement
  • Liver
  • Lymphoma
  • Strand-specific reverse transcriptase-polymerase chain reaction [RT- PCR]

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ascoli, V., Lo Coco, F., Artini, M., Levrero, M., Martelli, M., & Negro, F. (1998). Extranodal lymphomas associated with hepatitis C virus infection. American Journal of Clinical Pathology, 109(5), 600-609.

Extranodal lymphomas associated with hepatitis C virus infection. / Ascoli, Valeria; Lo Coco, Francesco; Artini, Marco; Levrero, Massimo; Martelli, Maurizio; Negro, Francesco.

In: American Journal of Clinical Pathology, Vol. 109, No. 5, 1998, p. 600-609.

Research output: Contribution to journalArticle

Ascoli, V, Lo Coco, F, Artini, M, Levrero, M, Martelli, M & Negro, F 1998, 'Extranodal lymphomas associated with hepatitis C virus infection', American Journal of Clinical Pathology, vol. 109, no. 5, pp. 600-609.
Ascoli V, Lo Coco F, Artini M, Levrero M, Martelli M, Negro F. Extranodal lymphomas associated with hepatitis C virus infection. American Journal of Clinical Pathology. 1998;109(5):600-609.
Ascoli, Valeria ; Lo Coco, Francesco ; Artini, Marco ; Levrero, Massimo ; Martelli, Maurizio ; Negro, Francesco. / Extranodal lymphomas associated with hepatitis C virus infection. In: American Journal of Clinical Pathology. 1998 ; Vol. 109, No. 5. pp. 600-609.
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