Extranodal marginal zone B-cell lymphoma of MALT-type of the lung

Single-center experience with 12 patients

Pier Luigi Zinzani, Monica Tani, Annalisa Gabriele, Venerino Poletti, Vittorio Stefoni, Lapo Alinari, Gerardo Musuraca, Francesca Bonifazi, Stefano Pileri, Sante Tura, Michele Baccarani

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The lung is a relatively rare site for mucosa-associated lymphoid tissue (MALT) lymphomas: we report the largest available single-center series of patients with this presentation. From August 1992 to October 2000, 12 patients with untreated primary low-grade MALT lymphoma of the lung were submitted either to chemotherapy alone (n = 8), surgery alone (n = 2) or surgery plus chemotherapy (n = 2). At diagnosis, 6 (50%) were asymptomatic and 6 (50%) had nonspecific pulmonary symptoms. The most common radiologic findings were a pulmonary infiltrate (7 cases) and a mass lesion (5 cases). Histological diagnosis was obtained with transbronchial lung biopsy/bronchoalveolar lavage (BAL) (6 cases), with transthoracic needle biopsy (1 case), or an open thoracotomy (5 cases). All patients had stage IE. All 12 (100%) achieved complete remission; 3 (25%) local recurrences were observed. The global 6-year survival rate was 100% with a relapse-free survival rate of 50%. In conclusion, these data underline the diagnostic utility of BAL and the therapeutic efficacy of a chemotherapeutic strategy based on regimens such as N-CVP in the context of localized MALT lymphoma of the lung.

Original languageEnglish
Pages (from-to)821-824
Number of pages4
JournalLeukemia and Lymphoma
Volume44
Issue number5
DOIs
Publication statusPublished - May 1 2003

Fingerprint

Marginal Zone B-Cell Lymphoma
Lung
Bronchoalveolar Lavage
Survival Rate
Recurrence
Drug Therapy
Needle Biopsy
Thoracotomy
Non-Hodgkin's Lymphoma
Biopsy

Keywords

  • Chemotherapy
  • Lung involvement
  • MALT lymphoma
  • Transbronchial biopsy

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Zinzani, P. L., Tani, M., Gabriele, A., Poletti, V., Stefoni, V., Alinari, L., ... Baccarani, M. (2003). Extranodal marginal zone B-cell lymphoma of MALT-type of the lung: Single-center experience with 12 patients. Leukemia and Lymphoma, 44(5), 821-824. https://doi.org/10.1080/1042819031000067972

Extranodal marginal zone B-cell lymphoma of MALT-type of the lung : Single-center experience with 12 patients. / Zinzani, Pier Luigi; Tani, Monica; Gabriele, Annalisa; Poletti, Venerino; Stefoni, Vittorio; Alinari, Lapo; Musuraca, Gerardo; Bonifazi, Francesca; Pileri, Stefano; Tura, Sante; Baccarani, Michele.

In: Leukemia and Lymphoma, Vol. 44, No. 5, 01.05.2003, p. 821-824.

Research output: Contribution to journalArticle

Zinzani, PL, Tani, M, Gabriele, A, Poletti, V, Stefoni, V, Alinari, L, Musuraca, G, Bonifazi, F, Pileri, S, Tura, S & Baccarani, M 2003, 'Extranodal marginal zone B-cell lymphoma of MALT-type of the lung: Single-center experience with 12 patients', Leukemia and Lymphoma, vol. 44, no. 5, pp. 821-824. https://doi.org/10.1080/1042819031000067972
Zinzani, Pier Luigi ; Tani, Monica ; Gabriele, Annalisa ; Poletti, Venerino ; Stefoni, Vittorio ; Alinari, Lapo ; Musuraca, Gerardo ; Bonifazi, Francesca ; Pileri, Stefano ; Tura, Sante ; Baccarani, Michele. / Extranodal marginal zone B-cell lymphoma of MALT-type of the lung : Single-center experience with 12 patients. In: Leukemia and Lymphoma. 2003 ; Vol. 44, No. 5. pp. 821-824.
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