Extrapleural pneumonectomy for malignant mesothelioma: An Italian multicenter retrospective study

Lorenzo Spaggiari, Giuseppe Marulli, Pietro Bovolato, Marco Alloisio, Vittore Pagan, Alberto Oliaro, Giovanni Battista Ratto, Francesco Facciolo, Rocco Sacco, Daniela Brambilla, Patrick Maisonneuve, Felice Mucilli, Gabriele Alessandrini, Giacomo Leoncini, Enrico Ruffini, Paolo Fontana, Maurizio Infante, Gian Luca Pariscenti, Monica Casiraghi, Federico Rea

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Abstract

Background This study assessed perioperative outcome and long-term survival in a large series of patients with malignant pleural mesothelioma who underwent extrapleural pneumonectomy (EPP) to identify prognostic factors allowing better patient selection. Methods We retrospectively collected data from nine referral centers for thoracic surgery in Italy. Perioperative outcome and survival data were available for 518 malignant pleural mesothelioma patients (84.4% with epithelial tumors, 68.0% with pathologic stage 3 disease) who underwent EPP with intention-to-treat (R0/R1) between 2000 and 2010. Induction chemotherapy was administered in 271 patients (52.3%) and adjuvant therapy in 373 patients (72.0%), including radiotherapy in 213 patients (41.1%), adjuvant chemotherapy in 43 patients (8.3%), and both in 117 patients (22.6%). Results In all, 136 patients (26.3%) had major complications after EPP, and 36 (6.9%) died within 90 days after surgery. The median overall survival was 18 months, with a 1-, 2-, and 3-year overall survival of 65%, 41%, and 27%, respectively. At multivariable analysis adjusted for age and disease stage, male sex (hazard ratio [HR] 1.47, 95% confidence interval [CI]: 1.12 to 1.92), nonepithelial histology (HR 1.96, 95% CI: 1.48 to 2.58), and trimodality treatment using induction chemotherapy (HR 0.61, 95% CI: 0.43 to 0.85) were significantly associated with survival. Development of a major complication also significantly worsened outcome (HR 1.85, 95% CI: 1.37 to 2.50). Conclusions The success of EPP in the context of a multimodality treatment depends on a series of patient characteristics. Female patients, patients with epithelial tumors, and patients who received induction chemotherapy will best benefit from EPP.

Original languageEnglish
Pages (from-to)1859-1865
Number of pages7
JournalAnnals of Thoracic Surgery
Volume97
Issue number6
DOIs
Publication statusPublished - 2014

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Spaggiari, L., Marulli, G., Bovolato, P., Alloisio, M., Pagan, V., Oliaro, A., Ratto, G. B., Facciolo, F., Sacco, R., Brambilla, D., Maisonneuve, P., Mucilli, F., Alessandrini, G., Leoncini, G., Ruffini, E., Fontana, P., Infante, M., Pariscenti, G. L., Casiraghi, M., & Rea, F. (2014). Extrapleural pneumonectomy for malignant mesothelioma: An Italian multicenter retrospective study. Annals of Thoracic Surgery, 97(6), 1859-1865. https://doi.org/10.1016/j.athoracsur.2014.01.050