Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review

Elena A. Bertola, Giacomo D. Simonetti, Rosaria Del Giorno, Olivier Giannini, Emilio F. Fossali, Martina Meoli, Mario G. Bianchetti, Benedetta Terziroli Beretta-Piccoli, Gregorio P. Milani

Research output: Contribution to journalReview article

Abstract

Streptococcus A infections have been associated with immune-mediated sequelae including acute glomerulonephritis, acute rheumatic fever, thrombocytopenia, hemolytic anemia, Henoch-Schönlein purpura, arthritis, uveitis, guttate psoriasis, and erythema nodosum. Available reviews do not report the occurrence of acute poststreptococcal glomerulonephritis in association with one of the mentioned conditions. We performed a systematic review of the literature on extrarenal immune-mediated disorders associated with acute poststreptococcal glomerulonephritis. The principles recommended by the Economic and Social Research Council guidance on the conduct of narrative synthesis and on the Preferred Reporting Items for Meta-Analyses and Systematic Reviews were used. We identified 41 original articles, published after 1965, which reported on 52 patients (34 males and 18 females aged from 1.7 to 57 years, median 9) affected by acute poststreptococcal glomerulonephritis associated with a further poststreptococcal disease: 29 cases with rheumatic fever (17 males and 12 females aged 3.0 to 57, median 17 years), 16 with hematologic diseases such as thrombocytopenia or hemolytic anemia (13 males and 3 females aged 1.8 to 13, median 6.0 years) and seven with Henoch-Schönlein syndrome, reactive arthritis or uveitis (4 males and 3 females aged 1.7 to 14, median 7.0 years). Patients affected by acute poststreptococcal glomerulonephritis associated with acute rheumatic fever were on the average older (P < 0.05) than patients with acute poststreptococcal glomerulonephritis associated with thrombocytopenia, hemolytic anemia, Henoch-Schönlein syndrome, reactive arthritis or uveitis. Five large case series describing 2058 patients affected by acute poststreptococcal glomerulonephritis did not mention its occurrence in association with further immune-mediated disorders. This systematic review points out that acute poststreptococcal glomerulonephritis can be associated, albeit rarely, with rheumatic fever, thrombocytopenia, hemolytic anemia, Henoch-Schönlein syndrome, reactive arthritis, or uveitis.

Original languageEnglish
Pages (from-to)294-302
JournalClinical Reviews in Allergy and Immunology
Volume57
Issue number2
DOIs
Publication statusPublished - Jan 1 2019

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Immune System Diseases
Glomerulonephritis
Rheumatic Fever
Hemolytic Anemia
Uveitis
Thrombocytopenia
Reactive Arthritis
Erythema Nodosum
Schoenlein-Henoch Purpura
Hematologic Diseases
Streptococcus
Psoriasis
Arthritis
Meta-Analysis
Economics
Infection
Research

Keywords

  • Acute poststreptococcal glomerulonephritis
  • Acute rheumatic fever
  • Hemolytic anemia
  • Henoch-Schönlein purpura
  • Reactive arthritis
  • Thrombocytopenia
  • Uveitis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis : a Systematic Review. / Bertola, Elena A.; Simonetti, Giacomo D.; Del Giorno, Rosaria; Giannini, Olivier; Fossali, Emilio F.; Meoli, Martina; Bianchetti, Mario G.; Terziroli Beretta-Piccoli, Benedetta; Milani, Gregorio P.

In: Clinical Reviews in Allergy and Immunology, Vol. 57, No. 2, 01.01.2019, p. 294-302.

Research output: Contribution to journalReview article

Bertola, EA, Simonetti, GD, Del Giorno, R, Giannini, O, Fossali, EF, Meoli, M, Bianchetti, MG, Terziroli Beretta-Piccoli, B & Milani, GP 2019, 'Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review', Clinical Reviews in Allergy and Immunology, vol. 57, no. 2, pp. 294-302. https://doi.org/10.1007/s12016-019-08761-w
Bertola, Elena A. ; Simonetti, Giacomo D. ; Del Giorno, Rosaria ; Giannini, Olivier ; Fossali, Emilio F. ; Meoli, Martina ; Bianchetti, Mario G. ; Terziroli Beretta-Piccoli, Benedetta ; Milani, Gregorio P. / Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis : a Systematic Review. In: Clinical Reviews in Allergy and Immunology. 2019 ; Vol. 57, No. 2. pp. 294-302.
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