Abstract
Purpose: The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123 I-FP-CIT SPECT imaging. Methods: The study groups comprised 56 PD patients without dementia, 41 DLB patients and 54 controls. Each patient underwent a standardized neurological examination and 123 I-FP-CIT SPECT. Binding in nigrostriatal and extrastriatal regions of interest was calculated in each patient from spatially normalized images. The occipital-adjusted specific to nondisplaceable binding ratio (SBR) in the different regions was compared among the PD patients, DLB patients and controls adjusting for the effects of age, sex, disease duration and serotonergic/dopaminergic treatment. Covariance analysis was used to determine the correlates of local and long-distance regions with extrastriatal 123 I-FP-CIT deficits. Results: Both PD and DLB patients showed lower 123 I-FP-CIT SPECT SBR in several regions beyond the nigrostriatal system, especially the insula, cingulate and thalamus. DLB patients showed significantly lower 123 I-FP-CIT SBR in the thalamus than controls and PD patients. Thalamic and cingulate 123 I-FP-CIT SBR deficits were correlated, respectively, with limbic serotonergic and widespread cortical monoaminergic projections only in DLB patients but exhibited only local correlations in PD patients and controls. Conclusion: PD and DLB patients both showed insular dopamine deficits, whereas impairment of thalamic serotonergic pathways was specifically associated with DLB. Longitudinal studies are necessary to determine the clinical value of the assessment of extrastriatal 123 I-FP-CIT SPECT.
| Original language | English |
|---|---|
| Pages (from-to) | 1642-1651 |
| Number of pages | 10 |
| Journal | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume | 46 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jul 1 2019 |
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Keywords
- I-FP-CIT SPECT
- Dementia with Lewy bodies
- Dopamine
- Parkinson’s disease
- Serotonin
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies : a 123 I-FP-CIT SPECT study. / Pilotto, Andrea; di Cola, Francesca Schiano; Premi, Enrico; Grasso, Roberto; Turrone, Rosanna; Gipponi, Stefano; Scalvini, Andrea; Cottini, Elisabetta; Paghera, Barbara; Garibotto, Valentina; Rizzetti, Maria Cristina; Bonanni, Laura; Borroni, Barbara; Morbelli, Silvia; Nobili, Flavio; Guerra, Ugo Paolo; Perani, Daniela; Padovani, Alessandro.
In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 46, No. 8, 01.07.2019, p. 1642-1651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies
T2 - a 123 I-FP-CIT SPECT study
AU - Pilotto, Andrea
AU - di Cola, Francesca Schiano
AU - Premi, Enrico
AU - Grasso, Roberto
AU - Turrone, Rosanna
AU - Gipponi, Stefano
AU - Scalvini, Andrea
AU - Cottini, Elisabetta
AU - Paghera, Barbara
AU - Garibotto, Valentina
AU - Rizzetti, Maria Cristina
AU - Bonanni, Laura
AU - Borroni, Barbara
AU - Morbelli, Silvia
AU - Nobili, Flavio
AU - Guerra, Ugo Paolo
AU - Perani, Daniela
AU - Padovani, Alessandro
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Purpose: The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123 I-FP-CIT SPECT imaging. Methods: The study groups comprised 56 PD patients without dementia, 41 DLB patients and 54 controls. Each patient underwent a standardized neurological examination and 123 I-FP-CIT SPECT. Binding in nigrostriatal and extrastriatal regions of interest was calculated in each patient from spatially normalized images. The occipital-adjusted specific to nondisplaceable binding ratio (SBR) in the different regions was compared among the PD patients, DLB patients and controls adjusting for the effects of age, sex, disease duration and serotonergic/dopaminergic treatment. Covariance analysis was used to determine the correlates of local and long-distance regions with extrastriatal 123 I-FP-CIT deficits. Results: Both PD and DLB patients showed lower 123 I-FP-CIT SPECT SBR in several regions beyond the nigrostriatal system, especially the insula, cingulate and thalamus. DLB patients showed significantly lower 123 I-FP-CIT SBR in the thalamus than controls and PD patients. Thalamic and cingulate 123 I-FP-CIT SBR deficits were correlated, respectively, with limbic serotonergic and widespread cortical monoaminergic projections only in DLB patients but exhibited only local correlations in PD patients and controls. Conclusion: PD and DLB patients both showed insular dopamine deficits, whereas impairment of thalamic serotonergic pathways was specifically associated with DLB. Longitudinal studies are necessary to determine the clinical value of the assessment of extrastriatal 123 I-FP-CIT SPECT.
AB - Purpose: The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123 I-FP-CIT SPECT imaging. Methods: The study groups comprised 56 PD patients without dementia, 41 DLB patients and 54 controls. Each patient underwent a standardized neurological examination and 123 I-FP-CIT SPECT. Binding in nigrostriatal and extrastriatal regions of interest was calculated in each patient from spatially normalized images. The occipital-adjusted specific to nondisplaceable binding ratio (SBR) in the different regions was compared among the PD patients, DLB patients and controls adjusting for the effects of age, sex, disease duration and serotonergic/dopaminergic treatment. Covariance analysis was used to determine the correlates of local and long-distance regions with extrastriatal 123 I-FP-CIT deficits. Results: Both PD and DLB patients showed lower 123 I-FP-CIT SPECT SBR in several regions beyond the nigrostriatal system, especially the insula, cingulate and thalamus. DLB patients showed significantly lower 123 I-FP-CIT SBR in the thalamus than controls and PD patients. Thalamic and cingulate 123 I-FP-CIT SBR deficits were correlated, respectively, with limbic serotonergic and widespread cortical monoaminergic projections only in DLB patients but exhibited only local correlations in PD patients and controls. Conclusion: PD and DLB patients both showed insular dopamine deficits, whereas impairment of thalamic serotonergic pathways was specifically associated with DLB. Longitudinal studies are necessary to determine the clinical value of the assessment of extrastriatal 123 I-FP-CIT SPECT.
KW - I-FP-CIT SPECT
KW - Dementia with Lewy bodies
KW - Dopamine
KW - Parkinson’s disease
KW - Serotonin
UR - http://www.scopus.com/inward/record.url?scp=85066039596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066039596&partnerID=8YFLogxK
U2 - 10.1007/s00259-019-04324-5
DO - 10.1007/s00259-019-04324-5
M3 - Article
AN - SCOPUS:85066039596
VL - 46
SP - 1642
EP - 1651
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
SN - 0340-6199
IS - 8
ER -