Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies: a 123 I-FP-CIT SPECT study

Andrea Pilotto, Francesca Schiano di Cola, Enrico Premi, Roberto Grasso, Rosanna Turrone, Stefano Gipponi, Andrea Scalvini, Elisabetta Cottini, Barbara Paghera, Valentina Garibotto, Maria Cristina Rizzetti, Laura Bonanni, Barbara Borroni, Silvia Morbelli, Flavio Nobili, Ugo Paolo Guerra, Daniela Perani, Alessandro Padovani

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123 I-FP-CIT SPECT imaging. Methods: The study groups comprised 56 PD patients without dementia, 41 DLB patients and 54 controls. Each patient underwent a standardized neurological examination and 123 I-FP-CIT SPECT. Binding in nigrostriatal and extrastriatal regions of interest was calculated in each patient from spatially normalized images. The occipital-adjusted specific to nondisplaceable binding ratio (SBR) in the different regions was compared among the PD patients, DLB patients and controls adjusting for the effects of age, sex, disease duration and serotonergic/dopaminergic treatment. Covariance analysis was used to determine the correlates of local and long-distance regions with extrastriatal 123 I-FP-CIT deficits. Results: Both PD and DLB patients showed lower 123 I-FP-CIT SPECT SBR in several regions beyond the nigrostriatal system, especially the insula, cingulate and thalamus. DLB patients showed significantly lower 123 I-FP-CIT SBR in the thalamus than controls and PD patients. Thalamic and cingulate 123 I-FP-CIT SBR deficits were correlated, respectively, with limbic serotonergic and widespread cortical monoaminergic projections only in DLB patients but exhibited only local correlations in PD patients and controls. Conclusion: PD and DLB patients both showed insular dopamine deficits, whereas impairment of thalamic serotonergic pathways was specifically associated with DLB. Longitudinal studies are necessary to determine the clinical value of the assessment of extrastriatal 123 I-FP-CIT SPECT.

Original languageEnglish
Pages (from-to)1642-1651
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume46
Issue number8
DOIs
Publication statusPublished - Jul 1 2019

Fingerprint

Lewy Body Disease
Single-Photon Emission-Computed Tomography
Parkinson Disease
Thalamus
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
Neurologic Examination
Longitudinal Studies
Dementia

Keywords

  • I-FP-CIT SPECT
  • Dementia with Lewy bodies
  • Dopamine
  • Parkinson’s disease
  • Serotonin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies : a 123 I-FP-CIT SPECT study. / Pilotto, Andrea; di Cola, Francesca Schiano; Premi, Enrico; Grasso, Roberto; Turrone, Rosanna; Gipponi, Stefano; Scalvini, Andrea; Cottini, Elisabetta; Paghera, Barbara; Garibotto, Valentina; Rizzetti, Maria Cristina; Bonanni, Laura; Borroni, Barbara; Morbelli, Silvia; Nobili, Flavio; Guerra, Ugo Paolo; Perani, Daniela; Padovani, Alessandro.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 46, No. 8, 01.07.2019, p. 1642-1651.

Research output: Contribution to journalArticle

Pilotto, A, di Cola, FS, Premi, E, Grasso, R, Turrone, R, Gipponi, S, Scalvini, A, Cottini, E, Paghera, B, Garibotto, V, Rizzetti, MC, Bonanni, L, Borroni, B, Morbelli, S, Nobili, F, Guerra, UP, Perani, D & Padovani, A 2019, 'Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies: a 123 I-FP-CIT SPECT study', European Journal of Nuclear Medicine and Molecular Imaging, vol. 46, no. 8, pp. 1642-1651. https://doi.org/10.1007/s00259-019-04324-5
Pilotto, Andrea ; di Cola, Francesca Schiano ; Premi, Enrico ; Grasso, Roberto ; Turrone, Rosanna ; Gipponi, Stefano ; Scalvini, Andrea ; Cottini, Elisabetta ; Paghera, Barbara ; Garibotto, Valentina ; Rizzetti, Maria Cristina ; Bonanni, Laura ; Borroni, Barbara ; Morbelli, Silvia ; Nobili, Flavio ; Guerra, Ugo Paolo ; Perani, Daniela ; Padovani, Alessandro. / Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies : a 123 I-FP-CIT SPECT study. In: European Journal of Nuclear Medicine and Molecular Imaging. 2019 ; Vol. 46, No. 8. pp. 1642-1651.
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abstract = "Purpose: The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123 I-FP-CIT SPECT imaging. Methods: The study groups comprised 56 PD patients without dementia, 41 DLB patients and 54 controls. Each patient underwent a standardized neurological examination and 123 I-FP-CIT SPECT. Binding in nigrostriatal and extrastriatal regions of interest was calculated in each patient from spatially normalized images. The occipital-adjusted specific to nondisplaceable binding ratio (SBR) in the different regions was compared among the PD patients, DLB patients and controls adjusting for the effects of age, sex, disease duration and serotonergic/dopaminergic treatment. Covariance analysis was used to determine the correlates of local and long-distance regions with extrastriatal 123 I-FP-CIT deficits. Results: Both PD and DLB patients showed lower 123 I-FP-CIT SPECT SBR in several regions beyond the nigrostriatal system, especially the insula, cingulate and thalamus. DLB patients showed significantly lower 123 I-FP-CIT SBR in the thalamus than controls and PD patients. Thalamic and cingulate 123 I-FP-CIT SBR deficits were correlated, respectively, with limbic serotonergic and widespread cortical monoaminergic projections only in DLB patients but exhibited only local correlations in PD patients and controls. Conclusion: PD and DLB patients both showed insular dopamine deficits, whereas impairment of thalamic serotonergic pathways was specifically associated with DLB. Longitudinal studies are necessary to determine the clinical value of the assessment of extrastriatal 123 I-FP-CIT SPECT.",
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AU - Premi, Enrico

AU - Grasso, Roberto

AU - Turrone, Rosanna

AU - Gipponi, Stefano

AU - Scalvini, Andrea

AU - Cottini, Elisabetta

AU - Paghera, Barbara

AU - Garibotto, Valentina

AU - Rizzetti, Maria Cristina

AU - Bonanni, Laura

AU - Borroni, Barbara

AU - Morbelli, Silvia

AU - Nobili, Flavio

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KW - Serotonin

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