Extratemporal herpes encephalitis during natalizumab treatment: A case report

Shalom Haggiag, Luca Prosperini, Simonetta Galgani, Carlo Pozzilli, Carmela Pinnetti

Research output: Contribution to journalArticlepeer-review


Herpes simplex virus encephalitis (HSE) is a rare but often fatal disease if left untreated. MRI typically shows the characteristic findings of medial temporal lobe and insular involvement, while diagnosis in confirmed by CSF PCR. In immunocompromised state, HSE may have atypical clinical and radiological features. We report a MS patient under natalizumab treatment with HSE, who presented with MRI lesions exclusively in the right parietal lobe. The patient was timely started on acyclovir resulting in marked improvement. A high index of suspicion for HSE should be maintained when a patient presents with fever and extratemporal lesions, even more in immunocompromised subjects.

Original languageEnglish
Pages (from-to)134-136
Number of pages3
JournalMultiple Sclerosis and Related Disorders
Publication statusPublished - Nov 1 2016


  • Encephalitic
  • HSV-1
  • Multiple sclerosis
  • Natalizumab

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Extratemporal herpes encephalitis during natalizumab treatment: A case report'. Together they form a unique fingerprint.

Cite this