Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects

A. Cossarizza, D. Monti, F. Bersani, R. Paganelli, G. Montagnani, R. Cadossi, M. Cantini, C. Franceschi

Research output: Contribution to journalArticle

Abstract

The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalFEBS Letters
Volume248
Issue number1-2
DOIs
Publication statusPublished - May 8 1989

Keywords

  • (Human lymphocyte)
  • Interleukin-2
  • Interleukin-2 receptor
  • Pulsed electromagnetic field

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology

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