Eye movement quantitative evaluation before and after high-dose 6-methylprednisolone in multiple sclerosis

M. Versino, R. Bergamaschi, R. Callieco, A. Romani, G. Castelnovo, G. Beltrami, V. Cosi

Research output: Contribution to journalArticlepeer-review

Abstract

We studied saccadic and smooth pursuit eye movements in 24 patients suffering from multiple sclerosis during disease worsening, before and after high-dose 6-methylprednisolone infusions. Quantitative evaluation of saccades was based on amplitude/duration and amplitude/peak velocity relationships, precision (i.e. the ratio of actual to desired saccade amplitude) and the latency, whereas smooth pursuit eye movements were studied using target velocity/performance index relationship. At basal recordings, 22/24 (91.7%) of the patients showed at least one abnormality. Eleven of the 24 patients (45.8%) showed modification of one or several parameters: improvement in 6 patients, worsening in 2, coexistence of both trends in 3. Latency improvement was the only significant modification when patients were considered as a group. Neurophysiological modifications did not correspond to clinical changes.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalActa Neurologica Scandinavica
Volume89
Issue number2
Publication statusPublished - 1994

Keywords

  • eye movements
  • methylprednisolone
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Eye movement quantitative evaluation before and after high-dose 6-methylprednisolone in multiple sclerosis'. Together they form a unique fingerprint.

Cite this