Ezrin gene, coding for a membrane-cytoskeleton linker protein, is regionally expressed in the developing mouse neuroepithelium

L. Gimeno, A. Corradi, I. Cobos, G. G. Consalez, S. Martinez

Research output: Contribution to journalArticle

Abstract

Ezrin is a member of the Ezrin, Radixin, Moesin (ERM) proteins family that are proposed to act as linkers between the cytoskeleton and plasma membrane. Ezrin regulates cell-cell and cell-matrix interactions playing a role in the regulation of cellular adhesion, movement and morphology in epithelia. Alterations in the expression of Ezrin and other members of ERM family have also been observed in brain tumours. Here we report the expression pattern of Ezrin during mouse neural development, from early stages to postnatal stages. In young and middle gestation embryos, Ezrin is expressed in the roof plate of the neural tube, in the presumptive domain of the choroidal plexus, and in some precise domains of ventricular epithelium. These domains are distributed in basal and alar neuroepithelial regions, some of them in relation to the expression of cadherins. At later gestation and postnatal stages, Ezrin expression is maintained on the mature choroidal plexus and is weakly detected in the proliferative regions of the mature brain.

Original languageEnglish
Pages (from-to)749-754
Number of pages6
JournalGene Expression Patterns
Volume4
Issue number6
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Cerebellar plate
  • Choroidal plexus
  • Ezrin
  • Ezrin Radixin Moesin family
  • Mouse
  • Neurofibromatosis 2
  • Neurogenesis

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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