F-18 FDG PET/CT and F-18 FLT PET/CT as predictors of outcome in patients with multiple myeloma. A pilot study.

R. Gallicchio, A. Nardelli, G. Calice, Attilio Guarini, G. Guglielmi, G. Storto

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We evaluated the prognostic significance of the combined use of F-18 FDG (FDG) and F-18 FLT (FLT) PET/CT (PET/CT) in patients (pts) with multiple myeloma (MM) suspected relapse after a first line chemotherapy. Methods: twenty-eight patients (57 ± 12 years) underwent both PET/CT scans over 2–4 weeks. Patients were grouped according to imaging results (FDG+/-; FLT+/-) and the findings compared to the event free survival (EFS). Results: five pts had FDG+; FLT+, 8 showed FDG+;FLT-, two had FDG-;FLT + and 13 presented FDG-;FLT-, mostly (87 %) of FDG+;FLT- pts had destructive lytic bone lesions. At Cox regression analysis the FDG PET/CT (HR 4.4, 95 % CI 1.3–15.4, p < 0.05) and FLT PET/CT (HR 5.8, 95 % CI 1.7–19.3, p < 0.01) were predictive of worst prognosis. The Kaplan-Meier analysis showed that FDG and FLT PET/CT independently influenced the survival. FDG-;FLT-patients had better EFS as compared to FDG+; FLT + pts and FDG-;FLT + pts, those of FDG+;FLT- group also had worsened EFS. Conclusions: results from the aggregate use of PET/CT FDG and FLT in MM represent a valuable prognostic indicator for identifying patients at higher risk of undue events and may help to correctly stratify the patients with suspected relapse.

Original languageEnglish
Article number109564
JournalEuropean Journal of Radiology
Volume136
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Multiple myeloma
  • Positron emission tomography
  • Survival

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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