F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma

Rosj Gallicchio, Giovanna Mansueto, Vittorio Simeon, Anna Nardelli, Roberto Guariglia, Daniela Capacchione, Ernesto Soscia, Piernicola Pedicini, Domenico Gattozzi, Pellegrino Musto, Giovanni Storto

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Aim: We evaluated the prognostic significance of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) obtained by F-18 FDG PET/CT (PET/CT) in patients with diffuse large B-cell Lymphomas (DLBCL) presenting intermediate IPI score. Material and Methods: Fifty-two patients (61 ± 13 yr) underwent PET/CT before the first-line chemotherapy. The mean SUVmax value, the summed MTV (cm3; 42% threshold), and the cumulative TLG (g) were registered. The patients were followed up 18 months thereafter (range 3-41 months). The PET/CT results were compared to the event-free survival (EFS). Results: At univariate analysis, SUVmax and lactate dehydrogenase (LDH) levels were predictive, but discordantly. The Kaplan-Meier survival analysis for SUVmax showed a significant better EFS in patients presenting higher values as compared to those having lesser (P = 0.0002, HR 0.13). Summed MTV and cumulative TLG were not suitable for predicting EFS. Conclusion: Despite the availability of new tools for the quantitative assessment of disease activity on PET/CT, the SUVmax rather than MTV and TLG remains the only predictor for EFS in DLBCL patients. The magnitude of glycolytic activity rather than the amount of metabolically active burden holds a predominant value for determining the response to chemotherapy in DLBCL.

Original languageEnglish
Pages (from-to)382-389
Number of pages8
JournalEuropean Journal of Haematology
Volume92
Issue number5
DOIs
Publication statusPublished - 2014

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Lymphoma, Large B-Cell, Diffuse
Glycolysis
Tumor Burden
Disease-Free Survival
Drug Therapy
Kaplan-Meier Estimate
Survival Analysis
L-Lactate Dehydrogenase

Keywords

  • DLBCL
  • Glycolytic activity
  • PET/CT
  • Quantitative assessment
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Medicine(all)

Cite this

F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma. / Gallicchio, Rosj; Mansueto, Giovanna; Simeon, Vittorio; Nardelli, Anna; Guariglia, Roberto; Capacchione, Daniela; Soscia, Ernesto; Pedicini, Piernicola; Gattozzi, Domenico; Musto, Pellegrino; Storto, Giovanni.

In: European Journal of Haematology, Vol. 92, No. 5, 2014, p. 382-389.

Research output: Contribution to journalArticle

Gallicchio, R, Mansueto, G, Simeon, V, Nardelli, A, Guariglia, R, Capacchione, D, Soscia, E, Pedicini, P, Gattozzi, D, Musto, P & Storto, G 2014, 'F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma', European Journal of Haematology, vol. 92, no. 5, pp. 382-389. https://doi.org/10.1111/ejh.12268
Gallicchio, Rosj ; Mansueto, Giovanna ; Simeon, Vittorio ; Nardelli, Anna ; Guariglia, Roberto ; Capacchione, Daniela ; Soscia, Ernesto ; Pedicini, Piernicola ; Gattozzi, Domenico ; Musto, Pellegrino ; Storto, Giovanni. / F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma. In: European Journal of Haematology. 2014 ; Vol. 92, No. 5. pp. 382-389.
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AU - Mansueto, Giovanna

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AU - Capacchione, Daniela

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AB - Aim: We evaluated the prognostic significance of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) obtained by F-18 FDG PET/CT (PET/CT) in patients with diffuse large B-cell Lymphomas (DLBCL) presenting intermediate IPI score. Material and Methods: Fifty-two patients (61 ± 13 yr) underwent PET/CT before the first-line chemotherapy. The mean SUVmax value, the summed MTV (cm3; 42% threshold), and the cumulative TLG (g) were registered. The patients were followed up 18 months thereafter (range 3-41 months). The PET/CT results were compared to the event-free survival (EFS). Results: At univariate analysis, SUVmax and lactate dehydrogenase (LDH) levels were predictive, but discordantly. The Kaplan-Meier survival analysis for SUVmax showed a significant better EFS in patients presenting higher values as compared to those having lesser (P = 0.0002, HR 0.13). Summed MTV and cumulative TLG were not suitable for predicting EFS. Conclusion: Despite the availability of new tools for the quantitative assessment of disease activity on PET/CT, the SUVmax rather than MTV and TLG remains the only predictor for EFS in DLBCL patients. The magnitude of glycolytic activity rather than the amount of metabolically active burden holds a predominant value for determining the response to chemotherapy in DLBCL.

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