F2-isoprostanes and total radical-trapping antioxidant potential in preterm infants receiving parenteral lipid emulsions

Paola Roggero, Fabio Mosca, Maria Lorella Giannì, Anna Orsi, Orsola Amato, Elisabetta Migliorisi, Mariangela Longini, Giuseppe Buonocore

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: We assessed the effects of three different parenteral lipid emulsions (long-chain triacylglycerols, medium-chain/long-chain triacylglycerols, olive oil) on lipid peroxidation in preterm infants. The hypothesis to be tested was that preterm infants receiving the olive oil-based lipid emulsion would undergo less peroxidation than preterm infants receiving lipid emulsions based on long- or medium-chain triacylglycerols. The secondary aim was to evaluate whether the lipid peroxidation persists beyond the cessation of parenteral nutrition (PN). Methods: A randomized controlled trial was designed. Thirty-six consecutive preterm infants (gestational age 28-33 wk) were enrolled in the study. Preterm infants were randomized to receive one of the three emulsions within the first 24h of life. Plasma F2-isoprostanes (F2-Ip) and total radical-trapping antioxidant potential (TRAP) were determined at baseline, on day 7 of PN, and on day 7 after stopping PN. Results: The F2-Ip and TRAP concentrations were not statistically different within and among the three groups at any time of the study. No significant interaction effect between the type of lipid emulsion administered and the repeated values of F2-Ip and TRAP was found. F2-Ip values showed a trend to decrease throughout the study in all the three groups. Conclusion: No significant difference in oxidative stress of preterm infants was detected according to the type of lipid emulsion received.

Original languageEnglish
Pages (from-to)551-555
Number of pages5
JournalNutrition
Volume26
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

F2-Isoprostanes
Emulsions
Premature Infants
Antioxidants
Lipids
Parenteral Nutrition
Triglycerides
Lipid Peroxidation
Time and Motion Studies
Gestational Age
Oxidative Stress
Randomized Controlled Trials

Keywords

  • Lipid emulsions
  • Lipid peroxidation
  • Parenteral nutrition
  • Preterm infant

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

F2-isoprostanes and total radical-trapping antioxidant potential in preterm infants receiving parenteral lipid emulsions. / Roggero, Paola; Mosca, Fabio; Giannì, Maria Lorella; Orsi, Anna; Amato, Orsola; Migliorisi, Elisabetta; Longini, Mariangela; Buonocore, Giuseppe.

In: Nutrition, Vol. 26, No. 5, 05.2010, p. 551-555.

Research output: Contribution to journalArticle

@article{a4aa1847f90045a0a9ea36327cbb3b15,
title = "F2-isoprostanes and total radical-trapping antioxidant potential in preterm infants receiving parenteral lipid emulsions",
abstract = "Objective: We assessed the effects of three different parenteral lipid emulsions (long-chain triacylglycerols, medium-chain/long-chain triacylglycerols, olive oil) on lipid peroxidation in preterm infants. The hypothesis to be tested was that preterm infants receiving the olive oil-based lipid emulsion would undergo less peroxidation than preterm infants receiving lipid emulsions based on long- or medium-chain triacylglycerols. The secondary aim was to evaluate whether the lipid peroxidation persists beyond the cessation of parenteral nutrition (PN). Methods: A randomized controlled trial was designed. Thirty-six consecutive preterm infants (gestational age 28-33 wk) were enrolled in the study. Preterm infants were randomized to receive one of the three emulsions within the first 24h of life. Plasma F2-isoprostanes (F2-Ip) and total radical-trapping antioxidant potential (TRAP) were determined at baseline, on day 7 of PN, and on day 7 after stopping PN. Results: The F2-Ip and TRAP concentrations were not statistically different within and among the three groups at any time of the study. No significant interaction effect between the type of lipid emulsion administered and the repeated values of F2-Ip and TRAP was found. F2-Ip values showed a trend to decrease throughout the study in all the three groups. Conclusion: No significant difference in oxidative stress of preterm infants was detected according to the type of lipid emulsion received.",
keywords = "Lipid emulsions, Lipid peroxidation, Parenteral nutrition, Preterm infant",
author = "Paola Roggero and Fabio Mosca and Giann{\`i}, {Maria Lorella} and Anna Orsi and Orsola Amato and Elisabetta Migliorisi and Mariangela Longini and Giuseppe Buonocore",
year = "2010",
month = "5",
doi = "10.1016/j.nut.2009.06.018",
language = "English",
volume = "26",
pages = "551--555",
journal = "Nutrition International",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - F2-isoprostanes and total radical-trapping antioxidant potential in preterm infants receiving parenteral lipid emulsions

AU - Roggero, Paola

AU - Mosca, Fabio

AU - Giannì, Maria Lorella

AU - Orsi, Anna

AU - Amato, Orsola

AU - Migliorisi, Elisabetta

AU - Longini, Mariangela

AU - Buonocore, Giuseppe

PY - 2010/5

Y1 - 2010/5

N2 - Objective: We assessed the effects of three different parenteral lipid emulsions (long-chain triacylglycerols, medium-chain/long-chain triacylglycerols, olive oil) on lipid peroxidation in preterm infants. The hypothesis to be tested was that preterm infants receiving the olive oil-based lipid emulsion would undergo less peroxidation than preterm infants receiving lipid emulsions based on long- or medium-chain triacylglycerols. The secondary aim was to evaluate whether the lipid peroxidation persists beyond the cessation of parenteral nutrition (PN). Methods: A randomized controlled trial was designed. Thirty-six consecutive preterm infants (gestational age 28-33 wk) were enrolled in the study. Preterm infants were randomized to receive one of the three emulsions within the first 24h of life. Plasma F2-isoprostanes (F2-Ip) and total radical-trapping antioxidant potential (TRAP) were determined at baseline, on day 7 of PN, and on day 7 after stopping PN. Results: The F2-Ip and TRAP concentrations were not statistically different within and among the three groups at any time of the study. No significant interaction effect between the type of lipid emulsion administered and the repeated values of F2-Ip and TRAP was found. F2-Ip values showed a trend to decrease throughout the study in all the three groups. Conclusion: No significant difference in oxidative stress of preterm infants was detected according to the type of lipid emulsion received.

AB - Objective: We assessed the effects of three different parenteral lipid emulsions (long-chain triacylglycerols, medium-chain/long-chain triacylglycerols, olive oil) on lipid peroxidation in preterm infants. The hypothesis to be tested was that preterm infants receiving the olive oil-based lipid emulsion would undergo less peroxidation than preterm infants receiving lipid emulsions based on long- or medium-chain triacylglycerols. The secondary aim was to evaluate whether the lipid peroxidation persists beyond the cessation of parenteral nutrition (PN). Methods: A randomized controlled trial was designed. Thirty-six consecutive preterm infants (gestational age 28-33 wk) were enrolled in the study. Preterm infants were randomized to receive one of the three emulsions within the first 24h of life. Plasma F2-isoprostanes (F2-Ip) and total radical-trapping antioxidant potential (TRAP) were determined at baseline, on day 7 of PN, and on day 7 after stopping PN. Results: The F2-Ip and TRAP concentrations were not statistically different within and among the three groups at any time of the study. No significant interaction effect between the type of lipid emulsion administered and the repeated values of F2-Ip and TRAP was found. F2-Ip values showed a trend to decrease throughout the study in all the three groups. Conclusion: No significant difference in oxidative stress of preterm infants was detected according to the type of lipid emulsion received.

KW - Lipid emulsions

KW - Lipid peroxidation

KW - Parenteral nutrition

KW - Preterm infant

UR - http://www.scopus.com/inward/record.url?scp=77951204561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951204561&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2009.06.018

DO - 10.1016/j.nut.2009.06.018

M3 - Article

C2 - 19880291

AN - SCOPUS:77951204561

VL - 26

SP - 551

EP - 555

JO - Nutrition International

JF - Nutrition International

SN - 0899-9007

IS - 5

ER -