Fabrication and characterization of biomimetic hydroxyapatite thin films for bone implants by direct ablation of a biogenic source

Gabriela Graziani, Matteo Berni, Alessandro Gambardella, Monica De Carolis, Maria Cristina Maltarello, Marco Boi, Gianluca Carnevale, Michele Bianchi

Research output: Contribution to journalArticle

Abstract

Biomimetic bone apatite coatings were realized for the first time by the novel Ionized Jet Deposition technique. Bone coatings were deposited on titanium alloy substrates by pulsed electron ablation of deproteinized bovine bone shafts in order to resemble bone apatite as closely as possible. The composition, morphology and mechanical properties of the coatings were characterized by GI-XRD, FT-IR, SEM-EDS, AFM, contact angle measurements, micro-scratch and screw-insertion tests. Different post-treatment annealing conditions (from 350 °C to 425 °C) were investigated. Bone apatite coatings exhibited a nanostructured surface morphology and a composition closely resembling that of the deposition target (i.e. natural bone apatite), also regarding the presence of magnesium and sodium ions. Crystallinity and composition of the coatings were strongly influenced by annealing temperature and duration; in particular, upon annealing at 400 °C and above, a crystallinity similar to that of bone was achieved. Finally, adhesion to the titanium substrate and hydrophilicity were significantly enhanced upon annealing, all characteristics being known to have a strong positive impact on promoting host cells attachment, proliferation and differentiation.

Original languageEnglish
Pages (from-to)853-862
Number of pages10
JournalMaterials Science and Engineering C
Volume99
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Bone regeneration
  • Calcium phosphates
  • Ion-substituted hydroxyapatite
  • Nanostructured coatings
  • Orthopedics
  • Pulsed electron deposition

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