Factor V and Combined Factor V and VIII Deficiencies

Flora Peyvandi, Marta Spreafico

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish
Title of host publicationTextbook of Hemophilia: Second Edition
PublisherWiley-Blackwell
Pages332-340
Number of pages9
ISBN (Print)9781405169141
DOIs
Publication statusPublished - Aug 13 2010

Keywords

  • Combined deficiency of FV and FVIII and factor VIII replacement
  • Dosage choice and treatment modalities of bleeding episodes - bleeding types, FV of affected individuals and FV plasma half-life
  • Factor V (FV), one essential nonenzymatic cofactor of prothrombinase complex
  • Factor V and combined factor V and VIII deficiencies
  • Factor V protein and gene structure
  • Human FV deficiency, autosomal recessive bleeding disorder
  • Human FV, synthesized by hepatocytes and megakaryocytes
  • Molecular characterization, carrier detection and prenatal diagnosis - prevention of birth of children affected by coagulation disorders
  • Nonsense-mediated mRNA decay (NMD) pathway
  • Nucleotide sequence flanking initiator ATG codon (AGCATGT) - as consensus Kozac translation initiator sequence

ASJC Scopus subject areas

  • Medicine(all)

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