Factor V leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia

Elvira Grandone, Maurizio Margaglione, Donatella Colaizzo, Giuseppe Cappucci, Dario Paladini, Pasquale Martinelli, Sergio Montanaro, G. Pavone, Giovanni Di Minno

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Abstract

We performed a case-controlled study to investigate whether the FV Leiden mutation and the C > T677 polymorphism of the 5, 10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers were 10 (10.5%) in cases and 3 (2.3%) in controls (OR: 4.9, 95% CI: 1.3-18.3). MTHFR TT homozygotes were 28 (29.8%) in cases and 24 (18.6%) in the control group (OR: 1.8, 95% CI 1.0-3.5). No difference in any of the polymorphisms was found between proteinuric (n = 45) and non-proteinuric (n = 51) patients. Moreover, MTHFR polymorphism does not affect the association between FV Leiden and preeclampsia. In conclusion, FV Leiden mutation and MTHFR TT genotype are associated with the occurrence of preeclampsia, suggesting that, during pregnancy, women carrying these gene variants are prone to develop such a complication.

Original languageEnglish
Pages (from-to)1052-1054
Number of pages3
JournalThrombosis and Haemostasis
Volume77
Issue number6
Publication statusPublished - Jun 1997

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Methylenetetrahydrofolate Reductase (NADPH2)
Genetic Predisposition to Disease
Pre-Eclampsia
Mutation
Homozygote
Genotype
Pregnancy
Control Groups
factor V Leiden
Genes

ASJC Scopus subject areas

  • Hematology

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Factor V leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia. / Grandone, Elvira; Margaglione, Maurizio; Colaizzo, Donatella; Cappucci, Giuseppe; Paladini, Dario; Martinelli, Pasquale; Montanaro, Sergio; Pavone, G.; Di Minno, Giovanni.

In: Thrombosis and Haemostasis, Vol. 77, No. 6, 06.1997, p. 1052-1054.

Research output: Contribution to journalArticle

Grandone, E, Margaglione, M, Colaizzo, D, Cappucci, G, Paladini, D, Martinelli, P, Montanaro, S, Pavone, G & Di Minno, G 1997, 'Factor V leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia', Thrombosis and Haemostasis, vol. 77, no. 6, pp. 1052-1054.
Grandone, Elvira ; Margaglione, Maurizio ; Colaizzo, Donatella ; Cappucci, Giuseppe ; Paladini, Dario ; Martinelli, Pasquale ; Montanaro, Sergio ; Pavone, G. ; Di Minno, Giovanni. / Factor V leiden, C > T MTHFR polymorphism and genetic susceptibility to preeclampsia. In: Thrombosis and Haemostasis. 1997 ; Vol. 77, No. 6. pp. 1052-1054.
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AU - Paladini, Dario

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