Factor V Leiden increases plasma F1+2 levels both in normal and deep venous thrombosis subjects

Francesca Mercuri, Roberta Giacomello, Fabio Puglisi, Roberta Colaone, Dora Fabbro, Maria Grazia Menegon, Antonio Ceriello, Fabio Gonano, Giuseppe Damante

Research output: Contribution to journalArticle

Abstract

Background and Objectives. A simple approach to understanding molecular mechanisms leading to thrombosis is the definition of how genetic factors influence biochemical parameters of coagulation. Conflicting data have been reported regarding the role and the genotype of factor V plays in the control of plasma F1+2 levels. The aim of this study was to test whether the factor V Leiden mutation affects F1+2 levels. Design and Methods. We studied the effect of factor V Leiden mutation (detected by the polymerase chain reaction technique) on plasma F1+2 levels in 418 normal subjects and 39 subjects affected by deep venous thrombosis. Results. In both normal subjects and those with venous thrombosis, heterozygotes for the Leiden mutation showed significantly higher plasma levels of F1+2 (p

Original languageEnglish
Pages (from-to)386-389
Number of pages4
JournalHaematologica
Volume85
Issue number4
Publication statusPublished - Apr 2000

Keywords

  • F1+2
  • Factor V
  • Leiden
  • Multifactorial trait
  • Thrombosis

ASJC Scopus subject areas

  • Hematology

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    Mercuri, F., Giacomello, R., Puglisi, F., Colaone, R., Fabbro, D., Menegon, M. G., Ceriello, A., Gonano, F., & Damante, G. (2000). Factor V Leiden increases plasma F1+2 levels both in normal and deep venous thrombosis subjects. Haematologica, 85(4), 386-389.