Factors Affecting Course and Survival in Alzheimer's Disease: A 9-Year Longitudinal Study

Laura Bracco, Roberta Gallato, Francesco Grigoletto, Andrea Lippi, Vito Lepore, Giovanni Bino, Maria Pia Lazzaro, Francesco Carella, Tina Piccolo, Carlo Pozzilli, Bruno Giometto, Luigi Amaducci

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To evaluate mean survival and to identify prognostic factors in a cohort of patients with Alzheimer's disease (AD). Multicentric 9-year cohort analytic study. Seven neurology departments throughout Italy between April 1982 and January 1984. We recruited a consecutive sample of 145 patients affected by probable AD (Multicenter Italian Study on Dementia protocol, National Institute of Neurological Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria). Five were misdiagnosed, and 21 could not participate in the longitudinal study. The clinicodemographic characteristics of the 119 enrolled patients (49 men, 70 women; mean age, 64.7 years; SD, 4.1 years; mean duration of disease, 3.1 years; SD, 1.8 years) did not differ from those of the 26 excluded patients. All underwent extensive cliniconeuropsychological testing every 6 months for at least 2 years until the patient died or our survey ended (April 30, 1991). Mean follow-up was 5.1 years (SD, 2.5 years). Death, severe functional impairment (a score > 17 on the Blessed Dementia Scale), and severe cognitive impairment (a score of ^7 on the Information-Memory-Concentration Test). Survival curves obtained by the Kaplan-Meier method indicated that (1) patients with early- and lateonset disease (ie, before or after age 65 years) showed no difference either in relative survival or in time to reach predetermined functional and cognitive end points; (2) severely aphasie patients became profoundly demented significantly sooner than those with mild to moderate aphasia (P

Original languageEnglish
Pages (from-to)1213-1219
Number of pages7
JournalArchives of Neurology
Issue number12
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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